Formulation and evaluation of periodontal dressing containing vitamin c and banana peel extract and its effectiveness on melanocytes an invitro study

A number of studies using herbal extracts with antioxidant property shown to have anti melanogenic effect. Studies have shown that the use of cinnamon, ascorbic acid, curcumin, exhibiting anti oxidant properties helped in the scavenging of reactive oxygen inhibiting the melanin formation by preventing reduction of the dopamine. Studies also reported that sucrier banana peel extracts, could inhibit melanogenesis through the ERK signaling pathway. [4] Ascorbic acid/Vitamin C has been introduced as treatment of melanin pigmentation due to its suppressing effect on the tyrosine activity which directly downregulates dopaquinone formation, a precursor in melanin synthesis, as well as its epigenetic inhibitory effect on genes responsible for melanocytes function. However, to date, to the best of our knowledge, there has been paucity of literature on effect of combination of vitamin C and banana peel dressing on melanocytes