Effect of Concentrated Growth Factors on Short Implant-Supported Overdentures

Phase 2

Completed

• Conditions: Partially Edentulous Patients
• Interventions: Diagnostic Test: testing implant stability; Drug: use concentrated growth factor.; Radiation: marginal bone loss calculation

• Registration Number: NCT06880965
• Lead Sponsor: Tanta University

Brief Summary

The purpose of this study will be to evaluate the effect of concentrated growth factors on stability and radiographic outcome of short implant supported mandibular assisted overdenture

Detailed Description

A controlled clinical trial will be performed upon patients attending the outpatient clinic of Faculty of Dentistry Tanta University.Ten male patients will be selected for this study. Split mouth study design will be used in this study where, Group I represented the right side of the patients' mandibular posterior region will be restored with short implant in place of first molar and Group II represented the left side of the patients' mandibular posterior region will be restored with short implant in place of first molar and concentrated growth factors. The patients will receive partial mandibular assisted overdenture with O-ring attachment on the implant. Stability of implant and Radiographic evaluations will be carried out for every patient at regular recall visits at the time of insertion, 6 and 12 months

Study Timeline

• Study Start: 2023-08-24
• Primary Completion: 2024-11-25
• Status Verified: 2024-12
• Study Completion: 2024-12-04
• Study First Submitted: 2025-03-08
• Study First Submitted QC: 2025-03-16
• Last Update Submitted: 2025-03-16
• Study First Posted: 2025-03-18
• Last Update Posted: 2025-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Patients between 20 to 65 years old. Class I Kennedy's classification Good oral hygiene.

Exclusion Criteria

• Bad oral hygiene. Para functional habits ex. (bruxism, clenching,)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
short implants assisted over denture in combination with concentrated growth factors	testing implant stability	the left side of the patients' mandibular posterior region was restored with short implant in place of first molar by using short implants assisted over denture with concentrated growth factor.
short implants assisted over denture in combination with concentrated growth factors	use concentrated growth factor.	the left side of the patients' mandibular posterior region was restored with short implant in place of first molar by using short implants assisted over denture with concentrated growth factor.
short implants assisted over denture in combination with concentrated growth factors	marginal bone loss calculation	the left side of the patients' mandibular posterior region was restored with short implant in place of first molar by using short implants assisted over denture with concentrated growth factor.
using mandibular posterior short implants assisted over denture without concentrated growth factors	testing implant stability	the right side of the patients' mandibular posterior region was restored with short implant in place of first molar by using short implants assisted over denture without concentrated growth factor.
using mandibular posterior short implants assisted over denture without concentrated growth factors	marginal bone loss calculation	the right side of the patients' mandibular posterior region was restored with short implant in place of first molar by using short implants assisted over denture without concentrated growth factor.

Primary Outcome Measures

Name	Time	Method
Concentrated growth factor (CGF) Effects	one year	evaluate the effects of concentrated growth factors on the stability of short implant-supported mandibular assisted partial overdentures. Periotest equipment was used to measure the stability of the implants in all of the patients immediately after surgery, six months later.

Trial Locations

Locations (1)

Tanta university; 🇪🇬 Tanta, Gharbiya, Egypt