A Multicenter, Phase III, Randomized Study to Evaluate the Efficacy of Response-adapted Strategy to Define Maintenance After Standard Chemoimmunotherapy in Patients With Advanced-stage Follicular Lymphoma.
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 807
- 试验地点
- 48
- 主要终点
- PFS
研究概览
简要总结
Recently, the availability of R has substantially changed therapeutic approach to FL patients, since its combination with chemotherapy has improved response rates, progression free survival (PFS) and overall survival (OS). Based on the results of recently completed randomized studies the standard treatment for patients with FL should consist of an initial therapy with R-CHOP combination followed by two-year maintenance with R. Although results of randomized trials confirmed that this approach results in an improved patients' outcome and made a step forward in the management of patients with FL, one important question that can be raised is if this approach is really needed for all patients with FL or if some of them could benefit from a reduced intensity treatment achieving the same results in terms of outcome and survival . This question is of particular interest for newly diagnosed patients for whom maintenance does not affect OS.
More recent data demonstrated that the outcome of patients with FL can be further predicted by evaluating the quality of response to therapy studying minimal residual disease (MRD). This project addresses the objective of evaluating if combining clinical response assessed on FDG-PET scan and molecular response measured through MRD detection could permit to single out groups of patients at different risk of progression and to consequently modulate maintenance therapies, with the aim to provide clinicians a more rational use of the available diagnostic and therapeutic resources.
详细描述
This is a multicenter, randomized, phase III, superiority study comparing standard vs response driven approach to maintenance. Adult patients (age ≥ 18 years) with naïve, untreated follicular lymphoma, stage II-IV, Follicular Lymphoma International Prognostic Index 2 (FLIPI2) >0 requiring a therapeutic intervention will be recruited and randomly assigned in a 1:1 ratio to either standard or experimental arm.
All patients will receive the same induction therapy with 6 cycles of R-CHOP or R-bendamustine and 2 additional doses of Rituximab.
At baseline patients will be assessed for molecular status and staged by means of CT scan. A baselineFluorine-18-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) scan should also be performed.
At the end of chemoimmunotherapy all patients will be assessed for disease response by common clinical and laboratory examination, CT scan and FDG-PET. An intermediate assessment of response with CT scan and FDG-PET (optional) will also be performed after the first four courses of R-chemoimmunotherapy.
At the end of induction therapy the status of minimal residual disease will be also evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Histological diagnosis of B-Cell CD20+ Follicular Lymphoma (FL), grade I, II, IIIa according to the WHO 2008 classification
- •ECOG performance status 0-2
- •Age ≥ 18 years
- •Ann Arbor stage II-IV
- •FLIPI2>0
- •Presence of evaluable/measurable disease after diagnostic biopsy
- •At least one of the following criteria for defining active disease:
- •systemic symptoms
- •cytopenia due to bone marrow involvement
- •LDH> upper normal value
- •any nodal or extranodal tumor mass with a diameter >7cm
- •involvement of ≥ 3 nodal sites, each with a diameter of ≥ 3cm
- •extranodal disease
- •rapidly progressive disease
- •Life expectancy > 6 months
- •Left ventricular ejection fraction (LVEF) ³ 50%
- •Serum negativity for HIV
- •Serum negativity for HBsAg; HBcAb positive but HBV-DNA negative patients are allowed with mandatory Lamivudine prophylaxis.
- •Serum negativity for HCV, except for those patients without signs of active viral replication assessed by HCV-RNA copies
- •Serum creatinine < 2mg/dl , serum bilirubin < 1.5mg/dl, aspartate amino-transferase (AST/GOT) £ 2.5xUNV, alanine amino-transferase (ALT/GPT) £ 2.5xUNV, and alkaline phosphatase £ 4 times the upper limit of normal (unless the increase is attributed directly to the presence of tumour by the Investigator)
- •Patients with no previous treatment for the lymphoma with the exception of locoregional radiotherapy (IFRT)
- •Adequate measure adoption to avoid pregnancy
- •Written informed consent given at time of registration
- •Patient must be accessible for treatment and follow up.
排除标准
- •Histological diagnosis of :
- •any lymphoma other than follicular lymphoma and all CD20 negative B-cell lymphomas
- •grade III b follicular lymphoma
- •evidence of transformation to high grade lymphoma
- •Ann Arbor stage I
- •Suspect or clinical evidence of CNS involvement by lymphoma
- •History of other malignancies within 5 years prior to study entry except for adequately treated carcinoma in situ of the cervix or basal or squamous cell skin cancer, low grade, early stage localized prostate cancer treated surgically with curative intent, good prognosis DCIS of the breast treated with lumpectomy alone with curative intent
- •Evidence of any severe active acute or chronic infection
- •Concurrent co-morbid medical condition which might exclude administration of full dose chemotherapy
- •Severe chronic obstructive pulmonary disease with hypoxemia
- •Severe diabetes mellitus difficult to control with adequate insulin therapy
- •Myocardial infarction within 6 months before study entry
- •Clinically significant secondary cardiovascular disease e.g. uncontrolled hypertension, (resting diastolic blood pressure >115 mmHg), uncontrolled multifocal cardiac arrhythmias, symptomatic angina pectoris or congestive cardiac failure NYHA class III-IV
- •HbsAg-positive, HIV-positive, or HCVAb-positive patients
- •Known hypersensitivity or anaphylactic reactions to murine antibodies or proteins
- •Any other co-existing medical or psychological condition that would preclude participation in the study or compromise ability to give informed consent
- •Follicular lymphoma, showing a negative baseline PET scan.
研究组 & 干预措施
GROUP 1 - STANDARD
R-CHOP or R-bendamustine + Standard Maintenance
干预措施: R-CHOP or R-bendamustine (Drug)
GROUP 1 - STANDARD
R-CHOP or R-bendamustine + Standard Maintenance
干预措施: Standard Maintenance (Drug)
GROUP 2
FDG-PET POSITIVE (score 4-5) patients (High risk) R-CHOP or R-bendamustine + Ibritumomab Tiuxetan + Maintenance
干预措施: R-CHOP or R-bendamustine (Drug)
GROUP 2
FDG-PET POSITIVE (score 4-5) patients (High risk) R-CHOP or R-bendamustine + Ibritumomab Tiuxetan + Maintenance
干预措施: Ibritumomab Tiuxetan + Maintenance (Drug)
GROUP 1a
FDG-PET NEGATIVE (score 1-3) AND MRD NEGATIVE R-CHOP or R-bendamustine + Observation
干预措施: R-CHOP or R-bendamustine (Drug)
GROUP 1a
FDG-PET NEGATIVE (score 1-3) AND MRD NEGATIVE R-CHOP or R-bendamustine + Observation
干预措施: Observation (Drug)
GROUP 1b
FDG-PET NEGATIVE (score 1-3) AND MRD POSITIVE R-CHOP or R-bendamustine + Maintenance weekly x4
干预措施: R-CHOP or R-bendamustine (Drug)
GROUP 1b
FDG-PET NEGATIVE (score 1-3) AND MRD POSITIVE R-CHOP or R-bendamustine + Maintenance weekly x4
干预措施: Maintenance weekly x4 (Drug)
结局指标
主要结局
PFS
时间窗: 12/31/2019
To evaluate whether a FDG-PET and MRD response-based maintenance therapy is more effective in terms of Progression-Free Survival (PFS) than a standard maintenance therapy with Rituximab in patients with untreated, advanced, follicular lymphoma. Progression Free Survival (PFS) PFS will be measured from the date of randomization to the date of documented first occurrence of disease progression or relapse or to the date of death from any cause. Responding patients and patients who are lost to follow up will be censored at their last assessment date.
次要结局
- CRR(12/31/2019)
- ORR(12/31/2019)
- OS(12/31/2019)
- Molecular response analysis(12/31/2019)
- EFS(12/31/2019)
- DR(12/31/2019)