Phase I/II Clinical Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Preliminary Antitumor Activity of 8MW2311 in Subjects With Locally Advanced or Metastatic Solid Tumors

Mabwell (Shanghai) Bioscience Co., Ltd.3 sites in 1 country216 target enrollmentAugust 5, 2022

ConditionsSolid Tumors

Interventions8MW2311

Drugs8MW2311

Overview

Phase: Phase 1
Intervention: 8MW2311
Conditions: Solid Tumors
Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.
Enrollment: 216
Locations: 3
Primary Endpoint: AEs
Status: Suspended
Last Updated: last year

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This study is a Phase 1/2, first-in-human, open-label, dose-escalation and cohort expansion study designed to characterize the safety, tolerability, pharmacokinetics, pharmacodynamics, preliminary antitumor activity and immunogenicity of 8MW2311 administered by intravenous (IV) infusion.

Registry

clinicaltrials.gov

Start Date

August 5, 2022

End Date

March 2026

Last Updated

last year

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Mabwell (Shanghai) Bioscience Co., Ltd.

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Male or female, aged≥18 years old;
•Histologically or cytologically confirmed locally advanced or metastatic solid tumor;
•Subjects must have measurable disease according to RECIST (version 1.1)；
•Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1;
•Life expectancy \>3 months;
•Adequate organ performance based on laboratory blood tests;
•Sexually active fertile subjects, and their partners, must agree to use methods of contraception during the study and at least 6 months after termination of study therapy；
•Ability to understand and the willingness to sign a written informed consent document；

Exclusion Criteria

•History of other malignancy within 3 years before the first dose of study drug.
•History of IL-2 or IL-2 analogues anticancer therapy.
•Chemotherapy or radiotherapy within 21 days prior to the first dose of study drug, or any other anticancer therapy within 14 days prior to the first dose of study drug.
•Major surgery within 28 days prior to first dose of study drug.
•Any live vaccines within 28 days before first dose of study drug or during the study.
•Systemic glucocorticoids or other immunosuppressants received within 14 days before first dose of study drug.
•Toxicity related to preexisting treatment ≥Grade
•Central nervous system metastasis and/or cancerous meningitis.
•Inadequately controlled body cavity effusions.
•Interstitial pneumonia or interstitial lung disease, other pneumonia history or active pneumonia that may interfere with the judgement of immune-related pulmonary toxicity.