Esophageal Motility in Eosinophilic Esophagitis Evaluated by High Resolution Manometry - Effect on Esophageal Motility of Standard Therapy.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Eosinophilic Esophagitis
- Sponsor
- Technical University of Munich
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Improvement of esophageal motility (IBP) measureable in high resolution manometry (HRM)
- Last Updated
- 11 years ago
Overview
Brief Summary
Esophageal Motility in eosinophilic esophagitis will be evaluated by High Resolution Manometry before and after medical treatment - motility is suspected to change/improve after therapy.
Detailed Description
After identification of eosinophilic inflammation of the esophagus -\> differentiation between GERD and eosinophilic esophagitis (via pH/MII-measurements or PPI-trial) -\> High-resolution manometry (HRM) for evaluation of esophageal motility in patients with eosinophilic esophagitis (exclusion of GERD-patients)-\> initiation of budesonide-therapy -\> after eight weeks of therapy reevaluation of esophageal motility by HRM
Investigators
Monther Bajbouj
PD Dr. med.
Technical University of Munich
Eligibility Criteria
Inclusion Criteria
- •patients with eosinophilic inflammation of the esophagus
Exclusion Criteria
- •refusal to participate in study
- •pregnancy
- •eosinophilic gastroenteritis
- •Achalasia
- •contraindication for gastroscopy / HRM / 24-h-pH/Impedance-monitoring
- •contraindication for therapy with budesonide
- •eosinophilic inflammation due to GERD
Outcomes
Primary Outcomes
Improvement of esophageal motility (IBP) measureable in high resolution manometry (HRM)
Time Frame: Two months
Average maximum intra-bolus-pressure (IBP) \[mmHg\] before and after therapy
Secondary Outcomes
- Improvement of esophageal motility (e.g. specified in the chicago classification) represented in high resolution manometry (HRM)(Two months)
- Endoscopic evaluation of inflammation before/after therapy(Two months)
- Symptoms before/after therapy(Two months)