Effects of Operational Naps on Blood Pressure and Performance Among Night Shift Workers
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- BP dipping
研究概览
简要总结
Night shift work schedules disrupt sleep and have a negative impact on cardiovascular health. Most who work in public safety occupations and in healthcare work night shifts. These workers experience abnormal blood pressure during night shifts and are at greater risk of cardiovascular disease. Napping during night shifts can help to restore blood pressure patterns to a more normal pattern and may help to reduce risk of cardiovascular disease. Naps may also have an impact on alertness and performance immediately upon waking. The overarching goal of this study is to determine which duration of a nap taken during simulated night shift work has the greatest impact blood pressure and post-nap performance.
Researchers will compare 5 nap durations to see which has the greatest impact on blood pressure patterns and post-nap psychomotor performance.
Researchers hypothesize that longer naps will lead to improved blood pressure outcomes and shorter naps will contribute to better performance after waking.
Findings will help employers and employees who work night shifts determine how best to incorporate brief naps during night shift work.
详细描述
Blunted blood pressure (BP) dipping is a well-described risk factor for cardiovascular disease (CVD) among older adults and individuals with chronic disease. Previous research shows that night shift workers are at risk and repeatedly exposed to blunted BP dipping as a consequence of sleep loss and irregular sleep. While occasional episodes of blunted BP dipping may not be harmful, repetitive exposure over years of night shift work, as experienced by public safety workers (PSWs) and healthcare workers (HCWs), is likely detrimental to cardiovascular health and increases risk of CVD. Recent research shows that exposure can be mitigated with brief on-duty naps, which briefly restore normal BP dipping. Despite these data, there is legitimate clinical equipoise regarding the optimal on-duty nap duration (dose) needed to maximize BP dipping and minimize threats to post-nap psychomotor performance (i.e., sleep inertia).
This study will use a Phase II, within subject, crossover, incomplete block randomized trial design to test the efficacy of 5 overnight on-duty nap conditions: no-nap, 15, 30, 45, and 60-minutes. The primary outcome is the proportion of participants with a clinically meaningful greater than or equal to 10% dip in BP during nap opportunities. The secondary outcome is focused on deficits in psychomotor performance at greater than or equal to 10 mins post-nap: a safety-critical moment for PSWs and HCWs.
Goal enrollment is set at 130, accounting for attrition. Each condition begins with 36 hours of at-home monitoring with non-invasive devices. The last 12 hours of each condition includes a 12-hour simulated night shift with nap opportunities provided at 0200 hours with the nap duration determined by the randomization schema. During the simulated night shift, participants will be continuously monitored with non-invasive devices, allowed to consume controlled amounts of caffeine, and complete standardized tests of psychomotor performance. Participants will be blinded to nap duration and caffeine dose. Volunteer participants will be asked to complete 4 of the 5 nap conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
盲法说明
Participants are blinded to the nap duration.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-pregnant adults (>18 years of age)
- •certified public safety/healthcare shift worker
- •is an active shift worker
- •resides within the Western Pennsylvania region within reasonable driving distance
排除标准
- •current use of medication for cardiovascular disease (e.g., hypertension)
- •prior or current diagnosis of sleep apnea, narcolepsy, restless leg syndrome, ischemic heart disease, heart failure, stroke, chronic kidney disease, chronic liver disease, rheumatologic disease requiring prescription medication, and cancer requiring treatment in past 2 years
- •undiagnosed severe sleep apnea (Apnea-Hypopnea Index >30) based on at-home test
- •Abstains from caffeine or reports adverse effects from caffeine use
研究组 & 干预措施
Napping order
5 x 4 x 3 x 2 = 120 possible orderings of the 5 interventions for each person.
干预措施: 45-min nap (Behavioral)
Napping order
5 x 4 x 3 x 2 = 120 possible orderings of the 5 interventions for each person.
干预措施: No-nap (Behavioral)
Napping order
5 x 4 x 3 x 2 = 120 possible orderings of the 5 interventions for each person.
干预措施: 15-min nap (Behavioral)
Napping order
5 x 4 x 3 x 2 = 120 possible orderings of the 5 interventions for each person.
干预措施: 30-min nap (Behavioral)
Napping order
5 x 4 x 3 x 2 = 120 possible orderings of the 5 interventions for each person.
干预措施: 60-min nap (Behavioral)
结局指标
主要结局
BP dipping
时间窗: During simulated night shift, 12 hours
The ratio of mean sleep to mean wake blood pressure (BP) by taking the difference between the mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) during nap opportunities, and the mean SBP and DBP during wake periods.
Psychomotor performance post-nap
时间窗: During simulated night shift, greater than or equal to 10 minutes post intervention nap
Severe psychomotor impairment post-nap as measured by the Psychomotor Vigilance Test Brief (PVT-B)
次要结局
- Performance on simulated patient scenarios(During simulated night shift, 12 hours)
研究者
Daniel Patterson, PhD, NRP
Professor
University of Pittsburgh