Ventilation with lower tidal volumes as compared to traditional tidal volumes of patients not suffering from acute lung injury
Completed
- Conditions
- Mechanical ventilation, complicationsRespiratoryVentilation
- Registration Number
- ISRCTN82533884
- Lead Sponsor
- Academic Medical Centre (AMC) (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Patients who are intubated and expected to receive mechanical ventilation for greater than 72 hours are eligible for the study if they do not suffer from Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrom (ARDS), according to the American/European consensus criteria.
Exclusion Criteria
1. Greater than 36 hours after start of Mechnical Ventilation (MV)
2. Under 18
3. Participation in other trials
4. Pregnancy
5. Increased uncontrollable intracranial pressure
6. Severe chronic respiratory disease (daily medication)
7. Pneumonia
8. Use of corticosteroids (systemic or local) or other immunosuppressive agents
9. Pulmonary thrombo-embolism
10. After pneumonectomy or lobectomy
11. Previous randomisation in this study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Local inflammatory responses<br>2. Local Fibrin turnover<br>3. Systemic levels of biomarkers of lung injury
- Secondary Outcome Measures
Name Time Method ate ALI/ARDS.