Hypothermia versus normothermia after extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A cluster randomized trial (SAVE-J NEUROTHERM trial)

未提供0 个研究点目标入组 468 人开始时间: 待定最近更新: 2025年2月6日

试验速览

暂无简介。

•Out-of-hospital cardiac arrest
•Age of 18-75 years, known or as estimated
•Initial cardiac arrest rhythm of ventricular fibrillation/pulseless ventricular tachycardia or pulseless electrical activity

•ECMO initiated after sustained return of spontaneous circulation (ROSC), patients with sustained ROSC before ECMO initiation
•OHCA of presumed non-cardiac etiology
•Time from emergency call or witnessed arrest to hospital arrival > 60 minutes
•Time from hospital arrival to ECMO initiation > 60 minutes
•Prehospital ECPR
•Unavailability of the ECMO heat exchanger for temperature control
•Glasgow Coma Scale (GCS) before temperature control >8
•Core body temperature upon hospital arrival under 32 degrees Celsius
•Surgical intervention before temperature control (e.g., surgical intervention for the primary disease or complications related to resuscitation/ECMO procedures)
•Do Not Attempt Resuscitation (DNAR) order confirmed prior to temperature control
•Limitations in intensive care before temperature control
•Known cerebral performance category (CPC) of 3-4 before cardiac arrest
•Known chronic obstructive pulmonary disease with home oxygen therapy
•Known or as estimated pregnancy
•Concomitant illness such as malignancy shortens life expectancy (180 day survival unlikely)
•Consent not obtained or withdrawn by the participant or surrogate
•Other reasons, physician decision not to enroll

Survival at hospital discharge

发起方

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