Biomagnetic Characterization of Gastric Dysrhythmias III

Not Applicable

Conditions: Diabetic Gastroparesis
Idiopathic Gastroparesis
Functional Dyspepsia
Diabetics Without Symptoms of Gastroparesis
Chronic Nausea
Total or Partial Gastrectomy

Brief Summary: There is a tremendous clinical need for a noninvasive technique that can assess gastric electrical activity and would be repeatable without any exposure to radiation. Investigators developed a new technique allowing to use noninvasive methods to assess bioelectrical activity in the gastrointestinal system. This has enabled to characterize the normal and pathologic physiology of the stomach through the use of noninvasive magnetogastrogram (MGG) records. Primary hypothesis for this proposal is that analysis of gastric slow wave uncoupling and propagation in multichannel MGG discriminates between normal and pathological gastric electrical activity. Eventually, investigators envision this research leading to new insights for gastrointestinal conditions such as gastroparesis, functional dyspepsia and chronic idiopathic nausea that would inform clinical management of these debilitating diseases.

Detailed Description: Studies have demonstrated that the magnetogastrogram (MGG) records the same gastric slow wave activity that detect with serosal and mucosal electrodes. The upgraded magnetometer will improve the spatial resolution resulting in increased sensitivity for detecting and characterizing both abnormal frequency dynamics and abnormal spatiotemporal patterns. The spatiotemporal data collected with multichannel Superconducting QUantum Interference Device (SQUID) biomagnetometer has allowed , for the first time, to characterize propagation of the gastric slow wave noninvasively. In addition to frequency dynamic changes, which are the only reliable parameters from cutaneous electrogastrogram (EGG), and which still do not necessarily correlate well with disease, the MGG reflects normal and abnormal gastric slow wave activity. Furthermore, for the first time, investigators have demonstrated that propagation characteristics determined magnetically distinguish normal subjects from patients with gastroparesis. Also for the first time, investigators have been able to detect the gradient in gastric propagation velocity noninvasively in animal subjects. However, investigators still have unresolved questions about how MGG propagation rhythm and pattern disturbances may specify functional disorders.

Recruitment & Eligibility

Inclusion Criteria

Participants between ages 12-80
Diabetic patients with gastroparesis, diabetic patients without gastroparesis and who are willing to have a gastric emptying test if they have not had one in the last 6 months and an IV inserted.
Patients with idiopathic gastroparesis
Total or partial gastrectomy patients
Children (ages 12-17) with functional dyspepsia
Children (ages 12-17) with chronic nausea

Exclusion Criteria

Those with claustrophobia who cannot lie still under the SQUID for the length of time required.
Normal participants with known intestinal complications
Pregnant females (females who are able to have children will be given a pregnancy test).
Morbid obesity (these patients are presumably unable to lie under the current generation of SQUID devices).
Patients with a history of cardiac arrhythmias, taking anticoagulants, or greater than 80 years of age will be excluded.

Arm && Interventions

Group	Intervention	Description
Gastrectomy	magnetogastrogram	magnetogastrogram Total or partial gastrectomy group
Chronic nausea	magnetogastrogram	magnetogastrogram Children with chronic nausea
Gastroparesis	magnetogastrogram	magnetogastrogram Diabetes with and without gastroparesis ; Idiopathic gastroparesis
Control participants	magnetogastrogram	magnetogastrogram Group without any gastrointestinal diseases.
Functional dyspepsia	magnetogastrogram	magnetogastrogram Children with functional dyspepsia

Primary Outcome Measures

Name	Time	Method
Measurement of gastric slow wave activity in normal and diseased smooth muscle of the stomach	1 day

Secondary Outcome Measures

Name	Time	Method
Measurement of noninvasive magnetogastrogram before and after partial/total gastrectomy.	day 1 and day 30
Measurement of invasive serosal electromyogram before and after partial/total gastrectomy.	day 1 and day 30
Measurement of gastric slow wave propagation velocity in gastroparesis patients	1 day
Noninvasive measurement of gastric slow wave dysrhythmia in pediatric patients with nausea and functional dyspepsia	1 day

Locations (1): Vanderbilt University Medical Center
🇺🇸
Nashville, Tennessee, United States