A Phase II Clinical Study Evaluating the Combination Therapy of JS212 in Patients With Advanced Lung Cancer

Shanghai Junshi Bioscience Co., Ltd.1 个研究点分布在 1 个国家目标入组 864 人开始时间: 2026年1月23日最近更新: 2026年5月18日

适应症

干预措施

试验速览

阶段: 2 期
状态: 招募中
发起方
入组人数: 864
试验地点: 1
主要终点: ORR

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This is a multicenter, open-label Phase II clinical study, with the main objective being to evaluate the investigator-assessed objective response rate of JS212 in combination therapy for advanced lung cancer. The aim is to explore the safety, tolerability, and preliminary efficacy of JS212 combined with JS207, Toripalimab, JS213 combined or not combined with chemotherapy.

详细描述

Part One:

The plan involves including patients with previously failed standard treatments in advanced NSCLC and ES-SCLC. It consists of two phases: safety introduction and clinical expansion, covering cohorts 1 to 3.

The safety introduction phase will explore the safety of the following combined regimens in the target population:

Queue 1: JS212 + JS207 Queue 2: JS212 + Toripalimab Queue 3: JS212 + JS213

Part Two:

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 75 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•The age between 18 and 75 years old, and any gender.
•Local advanced, metastatic or recurrent NSCLC.
•According to the Response Evaluation Criteria in Solid Tumors v1.1 (RECIST v1.1), there must be at least one measurable lesion.
•Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or
•Expected survival period of ≥ 12 weeks.
•The functions of important organs meet the requirements.
•Female participants with reproductive capacity (WOCBP) who have sexual life with an unsterilized male partner and who have signed the informed consent must have a negative serum pregnancy test result within 7 days before the first administration, and must agree to take effective contraceptive measures from the time of signing the ICF until 7 months after the last administration of the study.
•Unsterilized male participants who have sexual life with a fertile female partner must agree to use the effective contraceptive measures after signing the ICF until 4 months after the last administration of the study. During this period, sperm donation is prohibited.
•The participants voluntarily participate in this study and sign the informed consent.

排除标准

•1. Accompanying the following disease states:
•Tumor histological or cytological pathological confirmation of combined large cell neuroendocrine carcinoma or sarcomatoid lesion, or NSCLC with small cell lung cancer component;
•NSCLC patients with positive driver mutations;
•Patients with known meningeal metastasis;
•Patients with symptomatic brain metastases;
•Uncontrolled pleural effusion, pericardial effusion, or recurrent ascites;
•Unatable spinal cord compression;
•2. Participants in Cohort 1 and Cohort 4 need to exclude any of the following conditions:
•Within one month before the first use of the study drug, any clinically significant hemoptysis or tumor bleeding;
•High bleeding risk; tumor invading important organs, high risks of perforation, esophageal-tracheal fistula, massive hemoptysis, etc.;
•Obvious bleeding tendency or severe coagulation dysfunction history, etc;
•Recent gastrointestinal perforation, gastrointestinal obstruction, trachea-esophageal fistula, abdominal fistula or intra-abdominal abscess, or currently having high-risk factors for hollow organ perforation/ fistula formation, or active inflammatory bowel disease, etc;
•Presence of severe, non-healed or open wounds, active ulcers or untreated fractures;
•Have poorly controlled hypertension;
•Have used antiplatelet drugs or anticoagulant therapy within 14 days;
•Have experienced a drug-related adverse event that led to permanent discontinuation of the medication during previous Bevacizumab and similar agent treatments;
•3. Have received any of the following treatments:
•Immune-mediated treatments (only for part Two);
•Have received any investigational drug within 4 weeks or 5 half-lives before the first use of the study drug;
•Have been enrolled in another clinical study;
•Have undergone major surgery within 4 weeks;
•Have received local small-scale radiotherapy within 14 days;
•4.Have not recovered to ≤ CTCAE grade 1 toxicity or the level specified in the inclusion/exclusion criteria.
•5.Have known allergies to any study treatment or its excipients or have experienced an allergic reaction.
•6.Have experienced a drug-related AE that led to permanent discontinuation of the anti-PD-(L)1 antibody treatment.
•7.Have any of the following cardiac examination results:
•Left ventricular ejection fraction (LVEF) < 50%;
•8.Have a history of diagnosed or suspected ILD, drug-induced pneumonia, or other severe lung diseases.
•9.Have experienced a severe infection within 4 weeks.
•10.Have a history of immunodeficiency, or have a history of organ transplantation and allogeneic bone marrow transplantation, or autologous hematopoietic stem cell transplantation.
•11.Have active pulmonary tuberculosis infection.
•12.Have active hepatitis.
•13. Uncontrolled concurrent diseases.
•14. Participants who were diagnosed with any other malignant tumor within 5 years.
•15. Female participants who are pregnant, breastfeeding, or planning to become pregnant during the study period.
•16. Other conditions for trial participation were not considered appropriate by the investigator.