The Role of the Intestinal Barrier Function in Liver Cirrhosis - Intestinal barrier function and liver cirrhosis

niversiteit Maastricht0 个研究点目标入组 93 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•Patients with liver cirrhosis:
•- Liver cirrhosis of any cause
•- A score of greater-than or equal to 5 assessed according to the Child-Pugh classification
•- Age between 18 and 75 years;Healthy individuals:
•- Normal medical history and physical examination
•- Age between 18 and 75 years
•- BMI between 18-30 kg/m-2

•Patients with liver cirrhosis:
•- Known gastrointestinal diseases (such as inflammatory bowel disease and celiac disease),
•chronic renal disease (i.e. a glomular filtration rate of <= 60 ml/min per 1.73 m2 estimated from
•the Modification of Diet in Renal Disease (MDRD) equation) or diabetes mellitus
•- Major abdominal surgery interfering with gastrointestinal function (except for uncomplicated
•appendectomy, cholecystectomy and hysterectomy, other surgery upon judgement of the
•principle investigator);Healthy individuals:
•- Abnormal liver tests (i.e. ALT, AST, γ-GT) according to the reference values for normal ranges of the liver enzymes at the laboratory of clinical chemistry of the Maastricht University medical Center.
•- History of gastrointestinal diseases and/or liver diseases.
•- Major abdominal surgery interfering with gastrointestinal function (except for uncomplicated appendectomy, cholecystectomy and hysterectomy, other surgery upon judgement of the principle investigator)
•- History of alcohol abuse or current excessive alcohol consumption (> 2 alcoholic beverages per day or > 14 alcoholic beverages per week)
•- Use of medication (that may interact with intestinal permeability i.e. NSAIDs, proton pump inhibitors)
•- Administration of investigational drugs in the 180 days prior to the study

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