NL-OMON36372
Recruiting
Not Applicable
The Role of the Intestinal Barrier Function in Liver Cirrhosis - Intestinal barrier function and liver cirrhosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- liver cirrhosis
- Sponsor
- niversiteit Maastricht
- Enrollment
- 93
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with liver cirrhosis:
- •\- Liver cirrhosis of any cause
- •\- A score of greater\-than or equal to 5 assessed according to the Child\-Pugh classification
- •\- Age between 18 and 75 years;Healthy individuals:
- •\- Normal medical history and physical examination
- •\- Age between 18 and 75 years
- •\- BMI between 18\-30 kg/m\-2
Exclusion Criteria
- •Patients with liver cirrhosis:
- •\- Known gastrointestinal diseases (such as inflammatory bowel disease and celiac disease),
- •chronic renal disease (i.e. a glomular filtration rate of \<\= 60 ml/min per 1\.73 m2 estimated from
- •the Modification of Diet in Renal Disease (MDRD) equation) or diabetes mellitus
- •\- Major abdominal surgery interfering with gastrointestinal function (except for uncomplicated
- •appendectomy, cholecystectomy and hysterectomy, other surgery upon judgement of the
- •principle investigator);Healthy individuals:
- •\- Abnormal liver tests (i.e. ALT, AST, γ\-GT) according to the reference values for normal ranges of the liver enzymes at the laboratory of clinical chemistry of the Maastricht University medical Center.
- •\- History of gastrointestinal diseases and/or liver diseases.
- •\- Major abdominal surgery interfering with gastrointestinal function (except for uncomplicated appendectomy, cholecystectomy and hysterectomy, other surgery upon judgement of the principle investigator)
Outcomes
Primary Outcomes
Not specified
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