Functional lung MRI for regional treatment monitoring of patients with cystic fibrosis
Completed
- Conditions
- Cystic fibrosisNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN11682934
- Lead Sponsor
- Hannover Medical School
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
1. Patients with cystic fibrosis
2. Aged between 12 and 24
3. Patients must be in a clinically stable condition with a confirmed diagnosis of cystic fibrosis
4. The forced expiratory volume in one second (FEV1) must have a minimum volume of >40 percent predicted for age and gender at the pre MRI lung function test
Exclusion Criteria
1. Pregnant or breastfeeding women
2. Cigarette smokers
3. Patients with hypertonic saline treatment (HST) within the last 7 days
4. Contraindications to MRI or contrast media (allergy to MRI or CT contrast media, GFR< 30 mL/min/1.73 m2)
5. No (patient or parental) consent to participate
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional lung MRI parameters at baseline and 2h after treatment
- Secondary Outcome Measures
Name Time Method o secondary outcome measures