ACTRN12618001749291尚未招募未知
The hemodynamic and physiological effects of rapid versus slow fluid bolus therapy with 4% albumin in ICU patients with severe sepsis or septic shock
Taeseon Shin0 个研究点目标入组 68 人开始时间: 2018年10月24日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
- 入组人数
- 68
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Admitted to ICU
- •Age 18 years or older
- •Meeting clinical criteria for fluid bolus administration (one of the following):
- •oMAP <65mmHg
- •oHR >100bpm
- •oUrine output <0.5ml/kg/hr
- •oLactate levels of >3mmol/dL
- •oCardiac index <2.5L/min/m2
排除标准
- •Evidence of fluid overload or acute pulmonary edema
- •Patient has contraindications to receiving albumin (e.g., allergic reaction or Jenovah’s Witness)
- •Active bleeding requiring transfusion
- •Haemoglobin level <70g/L
- •Patients in whom death is considered imminent (within 24 hours)
- •Receiving continuous renal replacement therapy (CRRT) or hemodialysis
- •Expected discharge from ICU during 2 hour monitoring period
- •Inability to give consent or refusing to consent
- •Inability to obtain satisfactory echocardiographic images for cardiac output measurement
研究者
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