The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Whether an acute dose of bupropion vs. placebo differentially affects the neurobiology and behavior of reward processing in depressed participants.
研究概览
简要总结
The purpose of the study is to evaluate the effects of a single-dose of Wellbutrin XL (bupropion hydrochloride) on reward processing.
详细描述
A cardinal feature of Major Depressive Disorder is anhedonia, which is a lack of pleasure in normally enjoyable activities. In order to understand reward processing in depressed individuals it is also necessary to study reward processing in people who are not depressed. Bupropion, the active drug in the anti-depressant Wellbutrin XL, has been shown to increase brain reward functioning in animals. The goal of the present study is to investigate the effects of Wellbutrin XL administered to psychiatrically healthy individuals as they perform a computer task known to assess reward processing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse)
- •Non-Smoker
- •Right-handed (Chapman and Chapman 1987)
- •Ability to provide informed consent
排除标准
- •Predisposition to seizure (e.g. family history of a seizure disorder, history of head trauma) or current use of medications that lower the seizure threshold
- •History or current diagnosis of anorexia or bulimia
- •Alcohol or substance abuse within the past year
- •Current usage of Wellbutrin or Zyban or other drugs that contain bupropion
- •Recent discontinuation of alcohol or sedatives (including benzodiazepines)
- •Use of (in the last 2 weeks) medications that may have antidepressant properties (ex. some herbal supplements)
- •Known allergies to bupropion
- •Currently lactating, pregnant or believe you are likely to be pregnant (enrolled subjects who are not using reliable contraception and have engaged in sexual intercourse since their last menstrual period will be given a self-administered pregnancy test.)
- •Left-handed/ambidextrous
- •Evidence of neurological illness
- •Serious suicide or homicide risk
- •Concomitant medications other than those listed in the exclusion criteria will be considered on an individual basis. Oral contraceptives will be allowed.
研究组 & 干预措施
Placebo
干预措施: Placebo (Drug)
Bupropion
干预措施: Bupropion (Drug)
结局指标
主要结局
Whether an acute dose of bupropion vs. placebo differentially affects the neurobiology and behavior of reward processing in depressed participants.
时间窗: 1 day
次要结局
未报告次要终点