Treating chronic cough and breathlessness by an antibiotic
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Chronic Obstructive Pulmonary Disease
- Registration Number
- CTRI/2011/07/001897
- Lead Sponsor
- Dr Parthasarathi Bhattacharyya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Informed written consent being given
Male and female patients aged 40-70 years
Has been on optimum pharmacotherapy for COPD
COPD severity diagnosed by GOLD criteria
No significant occupational history
FEVI 30-50%predicted; FEVI/FVC less than70%
Non pregnant, non lactating woman
Exclusion Criteria
History of exacerbation in past 1 month
History of Doxy allergy
Having any obvious contraindication for Doxycycline
Unable to meet the demand of the protocol for any reason
Significant abnormality in liver or renal or other organ function
Feature of chronic congestive cardiac failure (supported by echocardiography
any other concomitant lung disease (significant as per PI)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change in both pre and post bronchodilator FEVITimepoint: As and when atleast 30 patients will take doxycycline for at least 6 months and shall have at least one repeat spirometry done in a real world situation.
- Secondary Outcome Measures
Name Time Method ilTimepoint: Nil