Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,800
- 主要终点
- Accuracy of Behaviour
研究概览
简要总结
We will examine how stimulation of specific brain areas with transcranial magnetic stimulation (TMS) or transcranial electric stimulation (tES) changes specific aspects of behavior and brain activity, in order to test hypotheses about brain behavior relationships (basic research).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •between 18 and 80 years of age (whereby for most studies the majority of recruited participants will be between 18 and 40 years of age)
- •right-handedness and/or one specific gender (male or female) can be inclusion criteria to reduce variation in the data.
排除标准
- •inability to understand the instructions and insufficient knowledge of the project language
- •Internal electronic and/or metallic objects in the head, neck, or shoulders (e.g. artificial cochleae, deep brain stimulators, medical pumps, shrapnel, metallic splinters due to accidents during metal welding)
- •One or more epileptic fits in the participant or a first-degree relative
- •Vascular, traumatic, tumoral, infectious, or metabolic brain damage
- •Use of medication that significantly alters cortical excitability
- •Acute sleep deprivation or withdrawal from alcohol
- •pregnancy
- •to reduce bias, students of psychology or economics can be excluded if there is a possibility that they are familiar with the relevant paradigm.
研究组 & 干预措施
Stimulation
TMS or tES, depending on experiment
干预措施: TMS or tES (Other)
Sham
Corresponding sham TMS or tES
干预措施: sham TMS or tES (Other)
结局指标
主要结局
Accuracy of Behaviour
时间窗: 0-60 minutes after stimulation
Accuracy in percent correct
Cognitive Function driving Behaviour
时间窗: 0-60 minutes after stimulation
Parameter of Model describing cognitive function governing behaviour
Brain activity
时间窗: 0-60 minutes after stimulation
BOLD contrast in fMRI data
Speed of Behaviour
时间窗: 0-60 minutes after stimulation
Reaction time in miliseconds
次要结局
未报告次要终点
研究者
Christian Ruff
Prof. Dr.
University of Zurich