Optimising positive end expiratory pressure (PEEP) in mechanically ventilated patients with acute respiratory distress syndrome (ARDS)
Not Applicable
- Conditions
- Acute Respiratory Distress Syndrome (ARDS)Respiratory - Other respiratory disorders / diseases
- Registration Number
- ACTRN12613001006730
- Lead Sponsor
- Canterbury District Health Board
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Stopped early
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1. Patient on mechanical ventilation.
2. Patients diagnosed with all degrees of ARDS (PF ratio <300) as per the Berlin Definition (2012) (The ARDS Definition Task Force, A. 2012), by intensive care clinicians.
3. Arterial line in situ.
Exclusion Criteria
1. Patients who are likely to be discontinued from MV within 24 hours.
2. Patients aged less than 16.
4. Patients who are moribund and/or not expected to survive for more than 72 hours.
5. Patients whose care could be compromised if given increased sedation and/or muscle relaxants for the purpose of assessing lung recruitment.
6. Lack of clinical equipoise by ICU medical staff managing the patient.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of desaturation events (measured by continuous pulse oximetry, where SpO2 is less than 88%)[The occurance of desaturation events of a patient is recorded throughout the trial or for at least 48 hours. ];Length of mechanical ventilation[The length of MV is recorded as the duration from start of the trial until the discontinuation of mechanical ventilation. ]
- Secondary Outcome Measures
Name Time Method