Association Between Computed Tomography-Determined Sarcopenia and 28-Day Mortality in Critically Ill Cancer Patients: An Analytical Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- 28-Day All-Cause Mortality
研究概览
简要总结
The goal of this observational study is to evaluate the association between computed tomography-determined sarcopenia and muscle quality impairment with 28-day mortality in adult patients (aged 18 and older) with solid or hematologic malignancies admitted to the Intensive Care Unit (ICU).
The main question it aims to answer is: Is lower psoas muscle quality, calculated using the Hounsfield Unit Average Calculation (HUAC), associated with increased 28-day mortality in critically ill cancer patients? Researchers will compare patients who survived at 28 days with those who died to evaluate whether tomographic muscle measurements (HUAC and total psoas area) and clinical nutritional scores (mNUTRIC) differ between groups and predict mortality.
Participants' records will be evaluated through:
- A retrospective review of electronic medical records to collect demographic, clinical, oncologic, laboratory, and disease severity scores (APACHE II, SOFA, mNUTRIC).
- Quantitative tomographic assessment of the right and left psoas muscle area and radiation attenuation density (in Hounsfield Units) using existing computed tomography (CT) scans performed during routine clinical care.
- Follow-up of 28-day vital status (alive or deceased) after ICU admission.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients aged 18 years or older.
- •Confirmed diagnosis of solid or hematological malignancy.
- •Admitted to the Intensive Care Unit (ICU) between January 1, 2022, and December 31,
- •Availability of an abdominal computed tomography (CT) scan performed during routine clinical care at the time of or prior to ICU admission.
排除标准
- •Missing or incomplete clinical, laboratory, or outcome data in the electronic medical record.
- •Non-evaluable abdominal CT scans due to motion artifacts, metal artifacts, or lack of cross-sectional visibility of the bilateral psoas muscles.
研究组 & 干预措施
Survivors
Critically ill cancer patients admitted to the ICU who survived at 28 days post-admission.
干预措施: Computed Tomography Muscle Assessment (HUAC) (Other)
Non survivors
Critically ill cancer patients admitted to the ICU who died within 28 days post-admission
干预措施: Computed Tomography Muscle Assessment (HUAC) (Other)
结局指标
主要结局
28-Day All-Cause Mortality
时间窗: At 28 days post-ICU admission
Vital status (alive or deceased) of critically ill cancer patients evaluated at 28 days following their admission to the Intensive Care Unit (ICU). The association with muscle quality metrics, specifically the Hounsfield Unit Average Calculation (HUAC) of the psoas muscles obtained via computed tomography (CT) scan, will be assessed.
次要结局
- Nutritional Risk Assessment via mNUTRIC Score(Baseline (at ICU admission))
- Total Psoas Muscle Cross-Sectional Area(Baseline (CT scans performed within routine care prior to or at ICU admission))
- Acute Physiology and Chronic Health Evaluation II (APACHE II) Score(At ICU admission (Baseline))
- Sequential Organ Failure Assessment (SOFA) Score(Baseline (at ICU admission))
研究者
Jose J Zaragoza, MD MSc
Principal Investigator
Hospital H+ Queretaro