Associations Between Diabetes, Arterial Stiffness and Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery?

• Conditions: Coronary Artery Disease; Arteriosclerosis; Carotid Stenosis; Thrombosis; Aortic Aneurysm, Abdominal

• Registration Number: NCT01106573
• Lead Sponsor: Odense University Hospital

Brief Summary

Diabetes Mellitus (DM) is frequently appearing in patients with cardiovascular disease and these patients, as a consequence herby, has a lesser prognosis. DM is often related to increased arterial stiffness and hypertension. The investigators thesis is that DM and pre-diabetes is prevalent in patients undergoing cardiovascular surgery and to some extend is under-diagnosed. At the same time the investigators imagine that DM is closely related to the degree of arterial stiffness, and that these parameters are closely related to a new biochemical marker, fibulin-1.

The investigators aim to describe the prevalence of type 2 DM and dysmetabolism in patients admitted to the hospital to undergo cardiovascular surgery and besides that to investigate if there is a connection between the degree of the dysmetabolism and arterial disease, by studying arterial stiffness and by measuring a new biochemical marker, fibulin-1, which the investigators newly have identified. The results of this project will give us a measure for the quantity of unknown DM in patients undergoing cardiovascular surgery and furthermore tell us more in terms of the connections between a newly identified plasma arterial marker, arterial stiffness and diabetes.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-04
• Study First Submitted: 2010-04-19
• Study First Submitted QC: 2010-04-19
• Last Update Submitted: 2010-04-19
• Study First Posted: 2010-04-20
• Last Update Posted: 2010-04-20
• Study Start: 2010-06
• Primary Completion: 2013-05
• Study Completion: 2013-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1400

Inclusion Criteria

• >18 years of age
• undergoing heart- or vascular surgery

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Exclusion Criteria

• Physical or mental disability not enabling participation in the study

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Department of Biochemnistry and Farmacology, Odense University Hospital; 🇩🇰 Odense, Denmark