Prospective Trial for heart dose reduction during radiotherapy in deep Inspiration breath-hold for left-sided breast cancer patients

• Conditions: C50; D05; Malignant neoplasm of breast; Carcinoma in situ of breast

• Registration Number: DRKS00011213
• Lead Sponsor: Klinikum Großhadern Klinik für Strahlentherapie und Radioonkologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 600

Inclusion Criteria

Indikation for Radiotherapy of the breast/thoracic wall +/- lymphatic pathways after BCS (breast conserving surgery) or mastektomie in left-sided breast cancer patients

Exclusion Criteria

breath-hold of more than 20 seconds not possible
informed consent not possible

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dosimetric Analysis (dose-volume-Histogramm) and evaluation of heart dose reduction due to DIBH (Deep Inspiration Breath Hold)

Secondary Outcome Measures

Name	Time	Method
• assessment of cardiac risk factors and anamnesis for stratification (procam-score)<br>• assessement of Long time cardiac toxicity (Standard follow-up time)<br>• Radiation doses to organs at risk (heart, lung, LAD, contrabreast) (during planning process)<br>• stratification of anatomical caracteristics influencing dose reduction due to DIBH<br>• locally disease free survival<br>• distant disease free survival<br>• Overall survival