A Longitudinal Study in Parkinson's Disease (PD) Patients

• Conditions: Parkinson's Disease
• Interventions: Other: neurological exam

• Registration Number: NCT01730599
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene. The purpose of this study is to explore the association between genetic mutations in the known genes and their influence on disease manifestation over few years of follow up

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-10-22
• Status Verified: 2012-11
• Study Start: 2012-11
• Study First Submitted QC: 2012-11-15
• Last Update Submitted: 2012-11-15
• Study First Posted: 2012-11-21
• Last Update Posted: 2012-11-21
• Primary Completion: 2015-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• parkinson'd disease patients that already participated in a pasr cross sectional study

Exclusion Criteria

• subjects with cognitive decline by the parameters defined in Diagnostic and Statistical Manual of Mental Disorders (DSM)- IV
• subjects with psychiatric disorder
• subjects unable to sign a consent form

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PD patients	neurological exam	PD patients carriers of the G2019S mutation in the LRRK2 gene

Primary Outcome Measures

Name	Time	Method
change from baseline in updrs motor and total scores	the participants will be followed for 5 years. the measurements will be taken evry 18 month.

Trial Locations

Locations (1)

Tel Aviv Sourasky Medical Center; 🇮🇱 Tel Aviv, Israel