Evaluation of atorvastatin tablet as an adjuvant treatment for patients with mild to moderate COVID-19 in Qaem Hospital, Mashhad

Phase 2

Recruiting

Conditions: COVID-19 pneumonia.
COVID-19, virus identified
U07.1

Registration Number: IRCT20200408046990N3

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

Laboratory or clinical diagnosis of COVID-19 with admission indication
age between 18-65 y
sign of the written consent
not concomitant use of kaletra or other PIs, cyclosporine, colchicine, ciproterone, danazol, gemfibrozil, potent CYP3A4 inhibitors or inducers like macrolides, CCBs, Azoles, rifampin, phenytoin
not using statin before including in the study

Exclusion Criteria

history of allergy to statins
pregnancy and lactation
active liver disease or rise of LFT during study
including in other studies
start of PIs
ADR occurrence e.g. rhabdomyolysis
severe renal failure (GFR<30 ml/min)
indication for intubation or ICU
not being able to swallow medication

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fever. Timepoint: daily. Method of measurement: thermometer.;Clinical response to treatment (including improvement of cough, myalgia, headache, Olfactory and taste disorders). Timepoint: daily. Method of measurement: based on patients examination and interview.;Radiologic response. Timepoint: two weeks after treatment. Method of measurement: lung CT scan.;Laboratory response. Timepoint: weekly. Method of measurement: assessment of serum level of CRP and CBC diff.;Drug adverse reaction. Timepoint: daily. Method of measurement: patient file and interview.

Secondary Outcome Measures

Name	Time	Method
Duration of hospitalization. Timepoint: end of the treatment. Method of measurement: patients' file.;Patients' clinical outcome. Timepoint: at the of the treatment. Method of measurement: patients' file.