Use of Platelet Rich Plasma Gel in preventing healing complications of Tubularised Incised Plate Urethroplasty in Children with distal and mid-penile hypospadias

Hypospadias is a fairly common congenital disorder of the male external genitalia. It leads to an abnormally positioned urethral meatus on the underside of the penis and is associated with downward bending of penis and deficient foreskin. It is surgically repaired in multiple ways with each repair having its own complications. Complete or partial failure of the repair can occur in the form of urethrocutaneous fistula, glans dehiscence, urethral or meatal stenosis and stricture urethra. These complications can often be prevented with a good layered closure of the urethra which ensures adequate blood supply and healing of tissue.

Platelet rich plasma gel is a platelet concentrate formed by centrifugation of whole blood. It has been shown to promote wound healing. Hence it would be ideal to use something that improves vascularity and tissue growth.

We expect a decreased proportion of complications (urethrocutaneous fistula) in the group in which PRP gel is used. The post operative HOSE(Hypospadias Objective Scoring Evaluation) is expected to be better in the study group. Patients with fewer complications will require fewer hospital visits and fewer surgeries