A comparison of the efficacy of advanced platelet-rich fibrin and leukocyte platelet-rich fibrin on postoperative pain, swelling, trismus, and soft tissue wound healing after removal of impacted mandibular third molar: A randomized controlled trial.
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 144
- 试验地点
- 1
研究概览
简要总结
Impacted mandibular third molar removal is commonly associated with post-operative pain, swelling, trismus, and delayed soft-tissue wound healing. Autologous platelet-rich fibrin (PRF) has been shown to enhance healing and reduce post-operative morbidity. This study is designed to compare the efficacy of advanced platelet-rich fibrin (APRF) and leukocyte-platelet rich fibrin (LPRF) in reducing post-operative pain, swelling, trismus, and improving soft-tissue wound healing following surgical removal of impacted mandibular third molars. This is a randomized, parallel-group, interventional clinical trial in which eligible participants will be randomly allocated to receive either APRF or LPRF at the extraction site. Post-operative pain will be assessed as the primary outcome, while swelling, trismus, and soft-tissue wound healing will be evaluated as secondary outcomes at predefined post-operative time points.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients between age of 18-45 years of both genders.
- •Patients indicated for surgical removal of moderately difficult impacted mandibular third molar as per Modified Pederson’s Index.
- •Healthy patients falling under ASA I and ASA II
- •Subjects able and willing to provide written informed consent and compliant with study procedure.
排除标准
- •Patients with mouth opening less than 30mm.
- •Patient with allergy with NSAIDS.
- •Patients having history of drug abuse.
- •Patients having any systemic or local immunodeficiency.
- •Patient is under regular analgesics and anti-depressants.
- •Having any blood coagulation impairment.
- •Presence of any acute oral infection.
- •Have been suffering with uncontrolled diabetes or other systemic diseases.
- •Having previous history of radiation therapy in the head and neck region.
- •Pregnant and nursing women.
- •Patient with the history of smoking and alcohol.
- •Soft tissue impactions.
研究者
Dr. Jyotsna
Geetanjali Dental and Research institute