Changes in aortic blood flow over several years in patients with diseases of the aortic valve measured by cardiac MRI

Not Applicable

Completed

• Conditions: Patients with tricuspid aortic valve or bicuspid aortic valve, with or without stenosis.; Circulatory System; Tricuspid aortic valveBicuspid aortic valveAortic stenosis

• Registration Number: ISRCTN17935517
• Lead Sponsor: Charité University Medicine Berlin

Brief Summary

2023 Results article in https://pubmed.ncbi.nlm.nih.gov/36865891/ (added 21/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-05-31
• Study Start: 2018-08-07
• Last Update Posted: 3 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

1. Over 18 years of age
2. Written consent
3. Known aortic stenosis and/or bicuspid aortic valve

Exclusion Criteria

1. Claustrophobia
2. Contraindications to CMR, including implants or metallic objects
3. Pregnant

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Images of the aorta and aortic flow were acquired using 4D flow MRI at the beginning of the study and 4-7 years following this. These images were analysed for the following and the results from each time point compared:<br>1. Flow patterns<br>2. Volumes<br>3. Wall shear stress