Evaluating the Role of Neuroinflammation in Low Back Pain

Phase 2

Completed

• Conditions: Low Back Pain; Back Pain Without Radiation; Back Pain With Radiation; Back Ache; Back Pain Lower Back Chronic; Pain, Chronic

• Registration Number: NCT03106740
• Lead Sponsor: Marco Loggia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-3-28
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 89

Inclusion Criteria

Inclusion Criteria:<br><br> - the ability to give written informed consent<br><br> - fluency in English<br><br> - on a stable pain treatment<br><br> - Chronic or sub-acute low back pain<br><br>Exclusion Criteria:<br><br> - no interventional pain procedures during drug trial<br><br> - contraindications to MRI and PET scanning (including presence of a cardiac pacemaker<br> or pacemaker wires, metallic particles in the body, vascular clips in the head or<br> previous neurosurgery, prosthetic heart valves, claustrophobia)<br><br> - pregnancy or breast feeding<br><br> - any use of recreational drugs in the past 6 months<br><br> - allergy to minocycline or other tetracyclines, or taking medications known to<br> interact with minocycline<br><br> - any other contraindications to minocycline administration

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in brain PET signal

Secondary Outcome Measures

Name	Time	Method
Changes in spinal PET signal;Daily pain ratings (as measured by the modified Brief Pain Inventory (BPI) severity subscale)