Effects of Tart Cherry Juice on the Body

Not Applicable

Completed

• Conditions: Age-Related Cognitive Decline; Cardiovascular Risk Factors
• Interventions: Other: Tart cherry juice; Other: Placebo

• Registration Number: NCT02922920
• Lead Sponsor: University of Delaware

Brief Summary

Tart cherries are a rich source of antioxidants. Studies have shown that tart cherries exert anti-oxidative and anti-inflammatory properties. The purpose of this study is to learn about the effects of drinking tart cherry juice on cardiovascular and cognitive health.

Detailed Description

Thirty-seven older adults were randomly assigned to drink 16 oz per day of either tart cherry juice or placebo drink for 12 weeks. Blood and urine samples were collected at baseline and 12 weeks to assess biomarkers. Physical activity and 3-day diet records were also collected throughout the study.

Study Timeline

• Study Start: 2014-11
• Primary Completion: 2016-05
• Study Completion: 2016-09
• Study First Submitted: 2016-09-20
• Status Verified: 2016-10
• Study First Submitted QC: 2016-10-03
• Last Update Submitted: 2016-10-03
• Study First Posted: 2016-10-04
• Last Update Posted: 2016-10-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Age 65-80

Exclusion Criteria

• Allergic to tart cherries
• Heavy smoker
• Taking medications that affect cognitive function
• History of neurological disorders
• History of traumatic brain injury
• History of stroke
• Clinical diagnosis of diabetes
• Clinical diagnosis of Alzheimer's Disease/Dementia
• GI disease
• Kidney disease
• Liver disease
• Cancer

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Tart cherry juice	Tart cherry juice	Participants consumed 16 fl. oz of tart cherry juice daily for 12 weeks.
Placebo juice	Placebo	Participants consumed 16 fl. oz of placebo daily for 12 weeks.

Primary Outcome Measures

Name	Time	Method
Cognitive function	Baseline and 12 weeks	Change from baseline in cognitive test performance at 12 weeks

Secondary Outcome Measures

Name	Time	Method
Cardiovascular risk factors	Baseline and 12 weeks	Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in cardiovascular risk factors including blood lipid profiles, atherogenic risk ratios, blood glucose, hemoglobin A1c, insulin, and blood pressure at 12 weeks.
Oxidative stress markers	Baseline and 12 weeks	Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in plasma 8-oxoguanine (ng/ml), plasma 8-hydroxy-2deoxy-guanosine (ng/mL), plasma hydroxynonenal (ng/ml), and plasma malondialdehyde (pmole/L) at 12 weeks.
Inflammatory markers	Baseline and 12 weeks	Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in plasma tumor-necrosis factor-α (pg/mL) and plasma high-sensitivity C-reactive protein (ng/mL) at 12 weeks.

Trial Locations

Locations (1)

University of Delaware; 🇺🇸 Newark, Delaware, United States