Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction
- Registration Number
- NCT02864953
- Lead Sponsor
- Remedy Pharmaceuticals, Inc.
- Brief Summary
The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric Infarction (LHI). The secondary objectives of Part 1 of the study are to determine if BIIB093 improves overall survival at Day 90 when compared with placebo, if BIIB093 improves functional outcome at Day 90 on the mRS dichotomized 0-4 vs. 5-6 when compared with placebo, if BIIB093 reduces midline shift at 72 hours (or at time of decompressive craniectomy \[DC\] or comfort measures only \[CMO\], if earlier) when compared with placebo, and to evaluate the safety and tolerability of BIIB093 in participants with LHI.
The objectives of Part 2 of the study are to evaluate long-term disability following LHI, to evaluate long-term outcome measures of clinical function, quality of life, and healthcare utilization, and to assess the safety of BIIB093 in subjects with LHI during the follow-up period.
- Detailed Description
This study, previously posted by Remedy Pharmaceuticals, Inc., has transitioned to Biogen.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 535
-
A clinical diagnosis of acute ischemic stroke in the middle cerebral artery (MCA) territory.
-
A large hemispheric infarction defined as; lesion volume of 80 to 300 centimeters cubed (cm^3) on magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI), or computed tomography perfusion (CTP), or an Alberta Stroke Program Early CT Score (ASPECTS) of 1 to 5 with involvement of at least 2 defined cortical regions.
-
Screening National Institutes of Health Stroke Scale (NIHSS) >=10.
-
At the time of randomization, and in the Investigator's judgement, it must be feasible for study drug treatment infusion to be initiated no later than 10 hours after time of symptom onset, if known, or the time last known normal.
- Participants who wake with stroke may be included if neurological and other exclusion criteria are satisfied. The time of stroke onset is to be taken as the midpoint between sleep onset (or last known to be normal) and time of waking.
-
For participants who receive thrombectomy, inclusion into the study must be based on post-thrombectomy MRI-DWI.
- Participant is likely to have supportive care withdrawn on the first day.
- Commitment to decompressive craniectomy (DC) prior to enrollment.
- Evidence of concurrent infarction in the contralateral hemisphere sufficiently serious so as to affect functional outcome.
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description BIIB093 BIIB093 BIIB093 administered as a bolus followed by continuous intravenous (IV) infusion over 72 hours. Placebo Placebo Placebo administered as a bolus followed by continuous intravenous (IV) infusion over 72 hours.
- Primary Outcome Measures
Name Time Method Part 1: Percentage of Participants With Improvement in Functional Outcome at Day 90 Assessed Via the Modified Rankin Scale (mRS) Day 90 The mRS measures the degree of functional independence following stroke. In this study, 7-category ordinal mRS scale was condensed to the following 5-categories: 0/1, 2, 3, 4, 5/6 where 0 and 1 reflect no disability and near-normal functioning while 5 and 6 represent severe disability and death, respectively.
- Secondary Outcome Measures
Name Time Method Part 1: Time to All-Cause Death Through Day 90 Randomization up to Day 90 Time to all-cause death is defined as the time from randomization to the time of death.
Part 1: Midline Shift at 72 Hours as Assessed by Non-contrast Computed Tomography (NCCT) or Magnetic Resonance Imaging (MRI) At 72 hours Midline shift is the perpendicular distance between the septum pellucidum and the line drawn between the anterior and posterior attachments of the falx to the inner table of the skull.
Part 1: Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs) From the signing of informed consent up to the last follow-up visit (up to 4 years 11 months) An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product. A SAE is any untoward medical occurrence that at any dose results in death, life-threatening event, requires inpatient hospitalization, significant disability/incapacity or congenital anomaly.
Part 1: Percentage of Participants Who Achieved mRS 0-4 at Day 90 Day 90 The mRS measures the degree of functional independence following stroke. In this study, the 7-category ordinal mRS scale was condensed to the following 5-categories: 0/1, 2, 3, 4, 5/6 where 0 and 1 reflect no disability and near-normal functioning while 5 and 6 represent severe disability and death, respectively.
Trial Locations
- Locations (249)
Maine Medical Center
🇺🇸Portland, Maine, United States
Lyerly Neurosurgery Baptist Health
🇺🇸Jacksonville, Florida, United States
University of Maryland
🇺🇸Baltimore, Maryland, United States
Fairview Southdale Hospital
🇺🇸Edina, Minnesota, United States
Columbia University Hervert Irving Comprehensive Cancer Center
🇺🇸New York, New York, United States
SUNY Upstate Medical Center
🇺🇸Syracuse, New York, United States
Stanford Stroke Center
🇺🇸Palo Alto, California, United States
Arizona Board of Regents, University of Arizona
🇺🇸Tucson, Arizona, United States
University of Florida, Jacksonville
🇺🇸Jacksonville, Florida, United States
Clinique CHC MontLégia
🇧🇪Liege, Belgium
UMASS Memorial Medical Center
🇺🇸Worcester, Massachusetts, United States
Beth Israel Deaconess Medical Center, Inc.
🇺🇸Jamaica Plain, Massachusetts, United States
Saint Louis University
🇺🇸Saint Louis, Missouri, United States
Fakultni nemocnice v Motole
🇨🇿Praha 5, Prague, Czechia
Summa Health System
🇺🇸Akron, Ohio, United States
University of Tennessee Health Sciences Center
🇺🇸Memphis, Tennessee, United States
ProMedica Toledo Hospital
🇺🇸Toledo, Ohio, United States
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
John Hunter Hospital
🇦🇺New Lambton Heights, New South Wales, Australia
Miami Valley Hospital South
🇺🇸Dayton, Ohio, United States
Valley Baptist Medical Center
🇺🇸Harlingen, Texas, United States
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Xuanwu Hospital Capital Medical University
🇨🇳Beijing, Beijing, China
Pest Megyei Flor Ferenc Korhaz
🇭🇺Kistarcsa, Budapest, Hungary
Rabin MC
🇮🇱Petah Tikva, Central, Israel
CHU de Brest - Hôpital de la Cavale Blanche
🇫🇷Brest cedex 2, Finistere, France
Rambam Health Care Center
🇮🇱Haifa, Israel
Fakultni nemocnice u sv. Anny v Brne
🇨🇿Brno, Moravia, Czechia
CHU Nancy - Hôpital Central
🇫🇷Nancy, Meurthe Et Moselle, France
Sunshine Hospital
🇦🇺St Albans, Victoria, Australia
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Klinikum Augsburg
🇩🇪Augsburg, Bayern, Germany
Hospital das Clínicas FMRP-USP
🇧🇷Ribeirao Preto, Sao Paulo, Brazil
Ospedale San Raffaele
🇮🇹Milano, Italy
Klinikum der Johann Wolfgang Goethe-Universitaet
🇩🇪Frankfurt, Hessen, Germany
Chiyukai Shin Yukuhashi Hospital
🇯🇵Yukuhashi-shi, Fukuoka-Ken, Japan
Somogy Megyei Kaposi Mor Oktato Korhaz
🇭🇺Kaposvar, Somogy, Hungary
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Chiyukai Fukuoka Wajiro Hospital
🇯🇵Fukuoka-shi, Fukuoka-Ken, Japan
Universitaetsklinikum Essen
🇩🇪Essen, Nordrhein Westfalen, Germany
Clinical Hospital 'Sestre Milosrdnice'
🇭🇷Zagreb, Croatia Proper, Croatia
Hôpital Bicêtre
🇫🇷Le Kremlin Bicêtre cedex, Val De Marne, France
Shaare Zedek
🇮🇱Jerusalem, Israel
Soroka University Medical Center
🇮🇱Beer-Sheva, Southern, Israel
SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz
🇭🇺Nyiregyhaza, Szabolcs-Szatmár-Bereg, Hungary
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Prague, Czechia
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
General Hospital Varazdin
🇭🇷Varazdin, Croatia Proper, Croatia
IRCCS Ospedale Policlinico San Martino
🇮🇹Genova, Italy
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Fakultni nemocnice Ostrava
🇨🇿Ostrava, Moravian-Silesian, Czechia
Hadassah University Hospital - Ein Kerem
🇮🇱Jerusalem, Israel
Petz Aladar Egyetemi Oktato Korhaz
🇭🇺Gyor, Győr-Moson-Sopron, Hungary
Klinikum Altenburger Land GmbH
🇩🇪Altenburg, Thueringen, Germany
Kobe City Hospital Organization Kobe City Medical Center General Hospital
🇯🇵Kobe-shi, Hyogo-Ken, Japan
CHU Nantes - Hopital Nord Laënnec
🇫🇷Saint-Herblain, Loire Atlantique, France
Universitaetsklinikum Erlangen
🇩🇪Erlangen, Bayern, Germany
Policlinico Umberto I
🇮🇹Rome, Roma, Italy
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
🇭🇺Szeged, Csongrád-Csanád, Hungary
Chiyukai Fukuoka Shinmizumaki Hospital
🇯🇵Onga-gun, Fukuoka-Ken, Japan
Helsinki University Hospital
🇫🇮Helsinki, Southern, Finland
Hopital Roger Salengro - CHU Lille
🇫🇷Lille Cedex, Nord, France
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria
🇵🇹Lisboa, Portugal
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
🇮🇹Rome, Roma, Italy
Tokyo Metropolitan Tama Medical Center
🇯🇵Fuchu-shi, Tokyo-To, Japan
Yamanashi Prefectural Central Hospital
🇯🇵Kofu-shi, Yamanashi-Ken, Japan
Seoul National University Bundang Hospital
🇰🇷Seongnam, Gyeonggi-do, Korea, Republic of
Azienda Ospedaliera Universitaria Careggi
🇮🇹Firenze, Italy
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Gifu Prefectural General Medical Center
🇯🇵Gifu-shi, Gifu-Ken, Japan
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Asahikawa Red Cross Hospital
🇯🇵Asahikawa-shi, Hokkaido, Japan
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Ohnishi Neurological Center
🇯🇵Akashi-shi, Hyogo-Ken, Japan
Centro Hospitalar e Universitário de Coimbra E.P.E. - Hospitais da Universidade de Coimbra
🇵🇹Coimbra, Portugal
NHO Minami Wakayama Medical Center
🇯🇵Tanabe-shi, Wakayama-Ken, Japan
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Spain
Ohio State Univ College Of Medicine
🇺🇸Columbus, Ohio, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
Sinai Hospital of Baltimore
🇺🇸Baltimore, Maryland, United States
UCSD Health-La Jolla
🇺🇸San Diego, California, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Brigham and Woman's Hospital
🇺🇸Boston, Massachusetts, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
University of Washington School of Medicine
🇺🇸Seattle, Washington, United States
CHU UCL Namur
🇧🇪Yvoir, Namur, Belgium
Hospital de Clínicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
University of Rochester Medical Center
🇺🇸Rochester, New York, United States
St. John's Hospital
🇺🇸Detroit, Michigan, United States
Barrow Neurological Institute
🇺🇸Phoenix, Arizona, United States
University of Utah Neurology
🇺🇸Salt Lake City, Utah, United States
TriStar Skyline Medical Center
🇺🇸Nashville, Tennessee, United States
Vanderbilt Medical Center
🇺🇸Nashville, Tennessee, United States
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
🇮🇹Rome, Roma, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
🇮🇹Brescia, Italy
Bispebjerg og Frederiksberg Hospital
🇩🇰Copenhagen NV, Copenhagen City, Denmark
Copenhagen University Hospital and Glostrup Hospital
🇩🇰Copenhagen, Copenhagen City, Denmark
Sjællands Universitetshospital
🇩🇰Roskilde, Østsjælland, Denmark
Anhui Provincial Hospital
🇨🇳Hefei, Anhui, China
Beijing Tiantan Hospital, Capital Medical University
🇨🇳Beijing, Bejing, China
Peking University Third Hospital
🇨🇳Beijing, Beijing, China
Hainan General Hospital
🇨🇳Haikou, Hainan, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsushe, China
The Second Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, Guangdong, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
🇨🇳Wuhan, Hubei, China
Huai'an First People's Hospital
🇨🇳Huai'an, Jiangsu, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, Jiangsu, China
The Second Affiliated Hospital of Nanjing Medical University
🇨🇳Nanjing, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical College
🇨🇳Xuzhou, Jiangsu, China
Jiangxi Provincial People's Hospital
🇨🇳Nanchang, Jiangxi, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Jiangxi Pingxiang People's Hospital
🇨🇳Pingxiang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
The Second Affiliated Hospital of Xi'an Jiaotong University（Xibei Hospital)
🇨🇳Xi'an, Shanxi, China
Army Specialty Medical Center of The Chinese People's Liberation Army
🇨🇳Chongqing, Sichuan, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Providence Brain and Spine Institute
🇺🇸Portland, Oregon, United States
Oregon Health & Science University
🇺🇸Portland, Oregon, United States
Universitaetsklinikum Jena
🇩🇪Jena, Thueringen, Germany
Universitaetsklinikum Carl Gustav Carus TU Dresden
🇩🇪Dresden, Germany
Southern Tohoku General Hospital
🇯🇵Koriyama-shi, Fukushima-Ken, Japan
Nippon Medical School Hospital
🇯🇵Bunkyo-ku, Tokyo-To, Japan
Showakai Brain Attack Center Ota Memorial Hospital
🇯🇵Fukuyama-shi, Hiroshima-Ken, Japan
Tsuchiura Kyodo General Hospital
🇯🇵Tsuchiura-shi, Ibaraki-Ken, Japan
St. Marianna University Hospital
🇯🇵Kawasaki-shi, Kanagawa-Ken, Japan
Rinku General Medical Center
🇯🇵Izumisano-shi, Osaka-Fu, Japan
National Cerebral and Cardiovascular Center
🇯🇵Suita, Osaka Prefecture, Japan
Saitama Medical University International Medical Center
🇯🇵Hidaka-shi, Saitama-Ken, Japan
Kyorin University Hospital
🇯🇵Mitaka-shi, Tokyo-To, Japan
Yamaguchi University Hospital
🇯🇵Ube-shi, Yamaguchi-Ken, Japan
NYU Langone Medical Center
🇺🇸New York, New York, United States
Groupe Hospitalier Pellegrin - Hôpital Pellegrin
🇫🇷Bordeaux, Gironde, France
University of Pittsburgh School of Medicine
🇺🇸Pittsburgh, Pennsylvania, United States
Renmin Hospital, Wuhan University
🇨🇳Wuhan, Hubei, China
Rutgers - Robert Wood Johnson Medical School
🇺🇸New Brunswick, New Jersey, United States
University of Kansas Medical Center Research Institute, Inc.
🇺🇸Kansas City, Kansas, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Northwell Health
🇺🇸Manhasset, New York, United States
Washington University Physicians
🇺🇸Saint Louis, Missouri, United States
Valley Hospital
🇺🇸Ridgewood, New Jersey, United States
Ascension St. John
🇺🇸Tulsa, Oklahoma, United States
Atrium Health Carolinas Medical Center
🇺🇸Charlotte, North Carolina, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
University of Pennsylvania Health System
🇺🇸Philadelphia, Pennsylvania, United States
The Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Iwate Prefectural Central Hospital
🇯🇵Morioka-shi, Iwate-Ken, Japan
Lehigh Valley Hospital - Cedar Crest
🇺🇸Allentown, Pennsylvania, United States
Rhode Island Hospital Warren Alpert Medical School Brown University
🇺🇸Providence, Rhode Island, United States
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Royal North Shore Hospital
🇦🇺St Leonards, New South Wales, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Hospital Sao Paulo
🇧🇷São Paulo, Sao Paulo, Brazil
Foothills Medical Centre
🇨🇦Calgary, Alberta, Canada
Okayama City General Medical Center Okayama City Hospital
🇯🇵Okayama-shi, Okayama-Ken, Japan
University of California Davis Health System
🇺🇸Sacramento, California, United States
University of Colorado Hospital
🇺🇸Aurora, Colorado, United States
Novant Health Forsyth Medical Center
🇺🇸Winston-Salem, North Carolina, United States
Wake Forest Baptist Health Sciences
🇺🇸Winston-Salem, North Carolina, United States
Grady Memorial Hospital
🇺🇸Atlanta, Georgia, United States
Mount Sinai Hospital
🇺🇸New York, New York, United States
University of Buffalo
🇺🇸Buffalo, New York, United States
Guilford Neurologic Research, PA
🇺🇸Greensboro, North Carolina, United States
Penn State University Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
The First Affiliated Hospital of Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
Affiliated Hospital of Nantong University
🇨🇳Nantong, Jiangsu, China
Clinical Hospital Centar Zagreb
🇭🇷Zagreb, Croatia Proper, Croatia
Fakultni nemocnice Brno
🇨🇿Brno, Moravia, Czechia
Klinikum Frankfurt Hoechst GmbH
🇩🇪Frankfurt, Hessen, Germany
Universitaetsklinikum Freiburg
🇩🇪Freiburg, Baden Wuerttemberg, Germany
Rhon-Klnikum Campus Bad Neustadt
🇩🇪Bad Neustadt Saale, Bayern, Germany
Klinikum Kassel GmbH
🇩🇪Kassel, Hessen, Germany
Universitaetsklinikum Muenster
🇩🇪Muenster, Nordrhein Westfalen, Germany
Istituto Clinico Humanitas
🇮🇹Rozzano, Milano, Italy
Hachinohe Red Cross Hospital
🇯🇵Hachinohe-shi, Aomori-Ken, Japan
Kimitsu Chuo Hospital
🇯🇵Kisarazu-shi, Chiba-Ken, Japan
A.O.U. Senese Policlinico Santa Maria alle Scotte
🇮🇹Siena, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
🇮🇹Milano, Italy
Toyota Memorial Hospital
🇯🇵Toyota-shi, Aichi-Ken, Japan
NHO Kyushu Medical Center
🇯🇵Fukuoka-shi, Fukuoka-Ken, Japan
NHO Sendai Medical Center
🇯🇵Sendai-shi, Miyagi-Ken, Japan
Kurashiki Central Hospital
🇯🇵Kurashiki-shi, Okayama-Ken, Japan
Kyungpook National University Hospital
🇰🇷Daegu, Gyeongsangnam-do, Korea, Republic of
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
🇱🇹Kaunas, Lithuania
Republican Vilnius University Hospital, Public Institution
🇱🇹Vilnius, Lithuania
Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião
🇵🇹Santa Maria da Feira, Aveiro, Portugal
Unidade Local de Saúde de Matosinhos, E.P.E. - Hospital Pedro Hispano
🇵🇹Matosinhos, Porto, Portugal
Hospital Garcia de Orta, EPE
🇵🇹Almada, Setubal, Portugal
Centro Hospitalar de São João, E.P.E
🇵🇹Porto, Portugal
Centro Hospitalar de Lisboa Ocidental, E.P.E. - Hospital de Egas Moniz
🇵🇹Lisboa, Portugal
Saint-Petersburg Scientific-Research Institute of Emergency Care
🇷🇺St. Petersburg, Leningrad, Russian Federation
Hospital Universitari de Bellvitge
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
SPb SBIH 'City Hospital # 26'
🇷🇺Saint Petersburg, Leningrad, Russian Federation
SHI "Territorial Clinical Hospital #1 n.a. S.V. Ochapovsky"
🇷🇺Krasnodar, Russian Federation
SBIH of Moscow 'City Clinical Hospital # 1 n. a. N. I. Pirogov'
🇷🇺Moscow, Russian Federation
SBEI HPE 'Kazan State Medical University' of the MoH of the RF
🇷🇺Kazan, Respublka Tatarstan, Russian Federation
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Córdoba, Spain
Complejo Hospitalario Universitario de Santiago
🇪🇸Santiago de Compostela, La Coruña, Spain
Hospital Regional Universitario de Malaga
🇪🇸Malaga, Málaga, Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Universitari de Girona Dr Josep Trueta
🇪🇸Girona, Spain
Hospital Clinico Universitario de Valladolid
🇪🇸Valladolid, Spain
Ospedale Regionale di Lugano
🇨🇭Lugano, Ticino, Switzerland
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Addenbrooke's Hospital
🇬🇧Cambridge, Cambridgeshire, United Kingdom
Queen Elizabeth University Hospital Campus
🇬🇧Glasgow, Strathclyde, United Kingdom
The National Hospital for Neurology & Neurosurgery
🇬🇧London, Greater London, United Kingdom
King's College Hospital
🇬🇧London, Greater London, United Kingdom
Imp Coll Health Nhst 1
🇬🇧London, Greater London, United Kingdom
Newcastle University- Clinical Ageing Research Unit
🇬🇧Newcastle upon Tyne, Tyne & Wear, United Kingdom
Yale New Haven Hospital
🇺🇸New Haven, Connecticut, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
Erlanger Health System
🇺🇸Chattanooga, Tennessee, United States
Nottingham University Hospitals City Campus
🇬🇧Nottingham, Nottinghamshire, United Kingdom
JFK Medical Center
🇺🇸Edison, New Jersey, United States
Clinica Neurológica e Neurocirúrgica de Joinville
🇧🇷Joinville, Santa Catarina, Brazil
Augusta University
🇺🇸Augusta, Georgia, United States
Universitair Ziekenhuis Gent
🇧🇪Gent, East Flanders, Belgium
UZ Leuven
🇧🇪Leuven, Flemish Brabant, Belgium
CHU Besançon - Hôpital Jean Minjoz
🇫🇷Besancon Cedex, Doubs, France
HGF - Hospital Geral de Fortaleza
🇧🇷Fortaleza, Ceará, Brazil
Hospital do Rocio
🇧🇷Campo Largo, Paraná, Brazil
University of South Florida
🇺🇸Tampa, Florida, United States
Jersey Shore University Medical Center
🇺🇸Neptune, New Jersey, United States
Vilnius University Hospital Santariskiu Clinic, Public Institution
🇱🇹Vilnius, Lithuania
Inselspital - Universitaetsspital Bern
🇨🇭Bern, Switzerland
Turun yliopistollinen keskussairaala
🇫🇮Turku, Western, Finland
CHU CAEN - Hôpital de la Côte de Nacre
🇫🇷Caen cedex 9, Calvados, France
CHU Rennes - Hopital Pontchaillou
🇫🇷Rennes cedex 09, Ille-et-Vilaine, France
Chang Gung Memorial Hospital,Linkou
🇨🇳Taoyuan, Taiwan
Ochsner Clinic Foundation
🇺🇸New Orleans, Louisiana, United States
Saint Luke's Hospital of Kansas City
🇺🇸Kansas City, Missouri, United States
UNC Hospitals
🇺🇸Chapel Hill, North Carolina, United States
St.David's HealthCare Office of Research
🇺🇸Austin, Texas, United States
University of Florida-Gainsville
🇺🇸Gainesville, Florida, United States
The Queens Medical Center
🇺🇸Honolulu, Hawaii, United States
University Hospital and UW Health Clinics
🇺🇸Madison, Wisconsin, United States
University of Alberta Hospital
🇨🇦Edmonton, Alberta, Canada
University of New Mexico
🇺🇸Albuquerque, New Mexico, United States
Monash Medical Centre
🇦🇺Clayton, Victoria, Australia
Huashan Hospital, Fudan University
🇨🇳Shanghai, Shanghai, China