CHoBI7 Trial: A Hospital Based Water, Sanitation and Hygiene Intervention for Households of Diarrheal Patients in Bangladesh
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 2,626
- Primary Endpoint
- Diarrhea prevalence among children under 2 years of age
Study Overview
Brief Summary
The Cholera Hospital Based Intervention for 7 Days (CHoBI7) randomized controlled trial for transition to scale aimed to: (1) Develop and evaluate scalable approaches to integrate the CHoBI7 intervention into the services provided for hospitalized diarrhea patients at health facilities in Bangladesh; and (2) Evaluate the ability of the CHoBI7 intervention to lead to a sustained uptake of the promoted hand washing with soap and water treatment behaviors and significant reductions in diarrheal disease over time.
Detailed Description
The findings from the recent randomized controlled trial of The Cholera Hospital Based Intervention for 7 Days (CHoBI7) demonstrated that this intervention was effective in significantly reducing symptomatic cholera infections in intervention households, and had significant sustained impacts on hand washing with soap behaviors and improved water quality 12 months post intervention. Next steps to transition to scale were: (1) Develop and evaluate scalable approaches to integrate the CHoBI7 intervention into the services provided for hospitalized diarrhea patients at health facilities in Bangladesh; and (2) Evaluate the ability of the CHoBI7 intervention to lead to a sustained uptake of the promoted hand washing with soap and water treatment behaviors and significant reductions in diarrheal disease over time.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Masking Description
Masking was not possible because the intervention included visible components including a handwashing station and a covered drinking water storage vessel.
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Diarrhea patients will be defined as patients having acute watery diarrhea three or more loose stools over a 24-hour period in the past three days. Diarrhea patients admitted to ICDDRB Dhaka Hospital or Mugda General Hospital will be eligible for the trial if:
- •have had 3 or more loose stools over the past 24 hours
- •plan to reside in Dhaka for the next 12 months
- •have no basin for running water in their home
- •have a child under five years of age in their household (including themselves) that produced a stool sample at baseline
- •have a working mobile phone in the household.
- •Household members of the diarrhea patient will be eligible for the trial if:
- •they have shared the same cooking pot and resided in the same home with the diarrhea patient for the last three days
- •plan to reside in their current household with the diarrhea patient for the next 12 months
Exclusion Criteria
- •(1) Children in foster care will be excluded from all research study activities.
Outcomes
Primary Outcomes
Diarrhea prevalence among children under 2 years of age
Time Frame: 12 months
Diarrhea prevalence among children under 2 years of age assessed by caregiver self report over a 12-month period
Diarrhea prevalence among all household members
Time Frame: 12 months
Diarrhea prevalence among all household members assessed by self report over a 12-month period
Diarrhea prevalence among children under 5 years of age
Time Frame: 12 months
Diarrhea prevalence among children under 5 years of age assessed by caregiver self report over a 12-month period
Secondary Outcomes
- Weight-for-age among children under 5 years of age(12 months)
- Weight-for-height among children under 5 years of age(12 months)
- Diarrhea prevalence among participants ages 10-18 years(12 months)
- Handwashing with soap(12 months)
- Diarrhea prevalence among participants ages 5-9 years(12 months)
- Weight-for-age among children under 2 years of age(12 months)
- Diarrhea prevalence among participants ages greater than 18 years(12 months)
- Household drinking water treatment(12 months)
- Height-for-age among children under 2 years of age(12 months)
- Height-for-age among children under 5 years of age(12 months)
- Weight-for-height among children under 2 years of age(12 months)