Intravenous tranexamic acid use in elective caesarean section: Does it reduce blood loss?
Completed
- Conditions
- Elective caesarean sectionPregnancy and ChildbirthCaesarean section
- Registration Number
- ISRCTN42314355
- Lead Sponsor
- Istanbul Bakirkoy Women and Children Hospital (Turkey)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 660
Inclusion Criteria
1. Subjects older than 38 weeks estimated gestational age
2. Requiring elective caesarean section
3. Females aged 20 - 40 years
Exclusion Criteria
Any risk factor associated with an increased risk of postpartum haemorrhage:
1. Anaemia (Hb less than 7 g%)
2. Multiple gestation
3. Antepartum haemorrhage
4. Uterine fibroids
5. Polyhydramnios
6. Emergency caesarean section
7. A history of uterine atony and postpartum bleeding
8. Current or previous history of significant disease including heart disease, liver, renal disorders or known coagulopathy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantity of blood postpartum, measured from one day before the caesarean section and two days after the caesarean section
- Secondary Outcome Measures
Name Time Method Measured from one day before the caesarean section and two days after the caesarean section:<br>1. Excessive bleeding rate<br>2. Blood transfusion<br>3. The use of additional uterotonic agents reflecting atony (such as an oxytocin infusion or Prostaglandin F2a)<br>4. Incidence of tranexamic acid side effects<br>5. Post-natal length of stay for the mother<br>6. Neonatal outcomes