Efficacy and tolerability of Ketogenic Diet in Children with Electrical Status in Sleep in terms of reduction of seizure burden , improvement in cognition , language and behaviour.

Not Applicable

Completed

• Conditions: Health Condition 1: G998- Other specified disorders of nervous system in diseases classified elsewhere

• Registration Number: CTRI/2022/07/043923
• Lead Sponsor: PGIMER

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 June 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 22

Inclusion Criteria

1.Children aged 2-16 years of either sex with ESES refractory to at least two antiseizure medications and corticosteroids.

Exclusion Criteria

1.Any child with EEG not consistent with ESES ( <50% SWI in slow wave sleep )

2.Children with ESES >50% SWI in slow wave sleep who become seizure-free with 2 antiseizure medications and corticosteroids

3.Children with ESES >50% SWI in slow wave sleep who take KD for less than one-week duration

4.Decline of consent by parent/guardian

5.Children with active or past history of hyperlipidemia and /or renal calculi, pancreatitis, liver failure, suspected or proven disorders of fat metabolism, primary carnitine deficiency, carnitine palmitoyl transferase deficiency, carnitine translocase deficiency, porphyrias, or pyruvate kinase deficiency

Study & Design

• Study Type: Interventional
• Study Design: Not specified