Efficacy of simvastatin in treating patients with traumatic brain injury.
Not Applicable
- Conditions
- Nervous System Diseasestraumatic brain injury
- Registration Number
- PACTR201708002405365
- Lead Sponsor
- Faculty of medicine El minia university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
acute Traumatic brain injury
age range from 18 to 60 years
admitted to Intensive care unit within 24 hours
Exclusion Criteria
history of allergy to statins
myopathies
patients with major organ dysfunction (renal, liver, cardiovascular)
drug or alcohol abuse
pregnancy or lactation
life threatening multiple trauma
administration of fibrates, niacin, or corticosteroid drugs
psychiatric disorder
past history of neurological illness, prolonged Q-T interval
expected to die imminently (< 24 hours)
signs of brain stem failure.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Glasgow Coma Scale level and plasma level of Amyloid precursor protein .
- Secondary Outcome Measures
Name Time Method APACHE II score, Intensive care unit mortality and Glasgow outcome scale