The effect of Exenatide on satiety, metabolic parameters and regional brain activation in response to nutrient ingestion in Type 2 diabetes.

King's College Hospital0 个研究点目标入组 60 人开始时间: 2007年12月13日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•People with Type 2 diabetes:
•1. 18-65 years of age
•2. Type 2 diabetes, with evidence of residual insulin secretion and insulin resistance as determined by absence of requirement for insulin therapy
•3. HbA1c (gold standard blood glucose control measure) 5.5-9.0%
•4. Diabetes controlled by either diet and exercise +/- combination of oral hypoglycaemic therapy (Metformin, Sulphonylurea, Meteglinides and/or thiazolidinediones.
•5. Diabetes therapy unchanged for three months prior to the study
•6. Clear understanding of written and spoken English
•7. Ability to given written consent
•Healthy volunteers (subjects without diabetes for generation of normative data with this scanning protocol):18-65 years of age with no significant medical history and not taking regular medications, who have a clear understanding of written and spoken English and are able to given written consent.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•1. Uncontrolled hypertension (blood pressure)
•2. Unstable diabetes control as judged by the investigator
•3. Insulin treated diabetes
•4. Cardiac failure (NYHA Grade 2 or higher - objective measure of heart failure)
•5. Inabililty fully to comprehend verbal and written English/understand the protocol
•6. Left handed subjects
•7. Weight >120kg.
•8. Contraindictation to fMRI scanning (metal implants; shrapnel injuries; cardiac pacemaker; claustrophobia)
•9. Subjects who suffer from claustrophobia
•10. Needle phobic subjects
•11. Patients taking recreational drugs
•12. Patients who have received any investigational drugs in the past 3 months.
•13. Pregnant females or those actively trying to become pregnant
•14. Subjects at high risk or with blood bourne infectious disease, such as HIV, Hepatitis B/C.

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