Safety and Efficacy of Kidney Transplantation in Patients With Aortoiliac Stenosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 655
- 试验地点
- 1
- 主要终点
- Patient Survival
研究概览
简要总结
The impact of aortoiliac stenosis on kidney transplant patients remains unclear. This study aims to investigate the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis.
详细描述
Kidney transplantation is the optimal treatment for end-stage renal disease (ESRD). Unfortunately, not all ESRD patients are eligible for kidney transplantation. Aortoiliac stenosis, an increasingly common type of peripheral arterial disease in ESRD patients, is considered as relative contra-indication for kidney transplantation. There are several reasons for concern, such as the complexity of the vascular anastomosis and inferior life expectancy. Consequently, it is still debated whether patients with aortoiliac stenosis would benefit from kidney transplantation.
This study aimed to supplement current literature on the safety and efficacy of kidney transplantation in patients with aortoiliac stenosis. To achieve this, all patients undergoing kidney transplantation in Erasmus Medical Center between January 2010 and December 2020 were enrolled, and propensity score matching was used to minimize confounding factors. Additionally, long-term graft function was investigated to evaluate the impact of stenosis on graft function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent kidney transplantation in the Erasmus Medical Center between January 2010 and December 2020
排除标准
- •Patients who were under 18 years at transplantation
- •Patients who underwent combined organ transplantation
- •Patients who had no follow-up
结局指标
主要结局
Patient Survival
时间窗: From the date of kidney transplantation till death or data cut-off, whichever came first, assessed up to 10 years.
Patient survival was calculated based on all-cause death from the date of kidney transplantation till the end of follow-up (January, 2023), assessed up to 10 years.
次要结局
- Death-censored Graft Survival(From the date of kidney transplantation till death or data cut-off, whichever came first, assessed up to 10 years.)
- Graft Function(From the date of kidney transplantation till death or data cut-off, whichever came first, assessed up to 10 years.)
研究者
Yitian Fang, MD
Principal Investigator
Erasmus Medical Center