The Effect of Diet Rich in Nordic Berries on Gut Microbiota, Glucose and Lipid Metabolism and Metabolism on Fenolic Compounds
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- Glucose level
研究概览
简要总结
Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures. The findings regarding the possible decrease of low-grade inflammation are existing also in humans. Low-grade inflammation has been suggested to be a mechanistic link between obesity and its consequences on cardiometabolic health. The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers.
详细描述
Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.
The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.
Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •overweight (BMI 26-39 kg/m2), and two of the following:
- •elevated fasting plasma glucose in the absence of diabetes (5.6-6.9 mmol/l)
- •abnormal serum lipid concentration: fasting serum triglyceride concentration >1.7 mmol/L, fasting serum HDL cholesterol <1.0 mmol/L (males) or <1.3 mmol/L (females))
- •waist circumference >102 cm (males) or >88 cm (females)
- •blood pressure >130/85 mmHg
排除标准
- •chronic diseases
- •use of lipid lowering medication
研究组 & 干预措施
SRC
Strawberry, raspberry and cloudberry intervention for 8 weeks
干预措施: 300 g of strawberry, raspberry and cloudberry (Dietary Supplement)
BB
Bilberry intervention for 8 weeks
干预措施: 400 g of bilberry (Dietary Supplement)
C
Control diet with restricted berry consumption
干预措施: Control diet (Other)
结局指标
主要结局
Glucose level
时间窗: week 8
Fasting glucose level oral glucose tolerance status at study week 8
Cholesterol level
时间窗: week 8
total, HDL and LDL cholesterol level at the study week 8
Inflammation markers
时间窗: week 8
Various inflammation markers were measured at the study week 8
次要结局
- Markers of sterol metabolism(week 8)
- gene expression in PBMCs(study week 8)
研究者
Marjukka Kolehmainen
Senior scientist
University of Eastern Finland