3D-MULTimodal Atrial SubstrAte MAPping in Atrial Fibrilliation – Feasibility and potential clinical relevance - The MULTASA-MAP Study

Not Applicable

• Conditions: I48.1; Persistent atrial fibrillation

• Registration Number: DRKS00011810
• Lead Sponsor: Klinikum der Universität München, Campus Großhadern

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-03-10
• Study Completion: 2022-12-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

?Documented persistent atrial fibrillation (duration > 4 weeks, < 12 months)
?Planned catheter ablation for symptomatic AF
?First left atrial ablation procedure
?Sinus rhythm prior to the procedure
?Age 18-75 years

Exclusion Criteria

?Contra-indications to catheter ablation therapy
?Patients with paroxysmal (<7 days persisting) AF
?LA diameter > 55 mm
?LA thrombus
?Previous LA substrate modification/surgery
?Severe structural heart disease,
?Hypertrophic cardiomyopathy
?Mitral prosthesis
?Unstable angina
?Uncontrolled hyperthyroidism
?Stroke or TIA within 6 months
?Myocardial infarction within 2 months
?Cardiac surgery within 3 months
?Thrombocytosis, thrombocytopenia
?Any condition contraindicating chronic anticoagulation
?Pregnancy
?Life expectancy <1year

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Feasibility of 3D-multimodal reconstruction representing an atrial map with respect to following parameters: voltage, excitation/conduction, CFAEs, spiral activation patterns in each patient.<br>2. Junction of the different maps.

Secondary Outcome Measures

Name	Time	Method
1. Coincidence of the different phenomena and outcome of the procedure.<br>2. Quantitative AF burden (in % of FU time, 12 weeks of blanking period post ablation).<br>3. Safety