Effect of Fenugreek on Blood Sugar and Insulin in Diabetic Humans

Completed

• Conditions: Diabetes Mellitus
• Interventions: Dietary Supplement: Trigonella foenum-graecum (fenugreek)

• Registration Number: NCT00597350
• Lead Sponsor: Pennington Biomedical Research Center

Brief Summary

The purpose of this study is to determine if bread containing fenugreek reduces blood sugar and insulin compared to identical bread without fenugreek.

Detailed Description

Trigonella foenum-graecum (fenugreek) has been used in traditional medicine for the treatment of diabetes. Fenugreek has been demonstrated to lower blood glucose in response to a glucose load while leaving the levels of serum insulin unaffected in rodents. This effect of lowering blood sugar without changing insulin levels demonstrates improved insulin action. Fenugreek has also been shown to decrease glucose absorption by inhibiting intestinal disaccharidases. Fenugreek decreases glycohemoglobin in diabetic rodents. An amino acid extracted from fenugreek seeds, 4-hydroxyisoleucine, decreases glucose and insulin in diabetic rodents, improves glucose tolerance and stimulates insulin secretion from isolated pancreatic rodent islets.

Fenugreek imparts a bitter taste to products into which it is placed, and this property has limited its use in treating diabetes. Dr. Losso and his associates developed a process that allows incorporation of fenugreek into bread and other bakery goods without imparting a bitter taste, and the success of this process was confirmed in taste testing. This study is designed to evaluate the effect of fenugreek bread made by Dr. Losso's proprietary process on glucose and insulin.

Study Timeline

• Study Start: 2007-11
• Primary Completion: 2008-01
• Study First Submitted: 2008-01-09
• Study First Submitted QC: 2008-01-17
• Study First Posted: 2008-01-18
• Study Completion: 2008-02
• Status Verified: 2015-12
• Last Update Submitted: 2015-12-17
• Last Update Posted: 2015-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Trigonella foenum-graecum (fenugreek)	Group with diabetes mellitus

Primary Outcome Measures

Name	Time	Method
Area under the curve for insulin and glucose	4 hrs. after eating the bread

Secondary Outcome Measures

Name	Time	Method
Any adverse event experienced by the subjects	2 times, 1 wk. apart

Trial Locations

Locations (1)

Pennington Biomedical Research Center; 🇺🇸 Baton Rouge, Louisiana, United States