The Oxytocin Initiative: Determining the Effect of Prophylactic Administration of Oxytocin in Uniject™ by a Community Health Officer on Postpartum Hemorrhage at Home Births in Four Districts in Ghana
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postpartum Hemorrhage
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
- Enrollment
- 1586
- Locations
- 1
- Primary Endpoint
- postpartum hemorrhage-1
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
This study is designed to test the hypothesis that the intramuscular administration of 10 IU of oxytocin in Uniject™ during the third stage of labor by a Community Health Officer (CHO) at home births in Ghana will reduce the risk of postpartum hemorrhage by 50 percent relative to home births attended by the same type of provider who does not provide a uterotonic drug.
Investigators
Eligibility Criteria
Inclusion Criteria
- •home delivery
- •presence of Community Health Officer at time of delivery
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
postpartum hemorrhage-1
Time Frame: after delivery of baby
blood loss \>=500 ml after delivery of the baby, as measured through plastic calibrated drape
postpartum hemorrhage-2
Time Frame: after delivery of the baby
blood loss \>=500ml OR treatment dose of oxytocin provided
postpartum hemorrhage-3
Time Frame: after delivery of the baby
blood loss \>=500ml OR treatment dose of oxytocin provided OR referral for bleeding
Secondary Outcomes
- Oxytocin use before delivery(labor and delivery)
- stillbirth(labor/delivery)
- neonatal death(first month of life)
- need for neonatal resuscitation(0-6 hours after birth)