A pilot study to characterize T cell responses in young children after influenza infectio

Completed

• Conditions: influenza; 10047438

• Registration Number: NL-OMON33577
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 125

Inclusion Criteria

Index population: children hospitalized at Wilhelmina Children*s Hospital, Spaarneziekenhuis, St. Antonius Ziekenhuis, and Diakonessenhuis with influenza infection.
Control Group: children hospitalized at Wilhelmina Children*s Hospital without influenza infection.
Adults: adults employed at RIVM/NVI without influenza infection.

Exclusion Criteria

Index population: prematurity (gestational age < 37 weeks), chronic lung disease, severe congenital diseases, known immunological dysfunction, current infectious disease other than influenza, hematologic disorder, usage of anticoagulants, influenza vaccination;Control group: prematurity (gestational age < 37 weeks), chronic lung disease, severe congenital diseases, known immunological dysfunction, current infectious disease, hematologic disorder, usage of anticoagulants, influenza vaccination;Adults: known immunological dysfunction, current infectious disease, hematologic disorder, usage of anticoagulants, influenza vaccination

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Height of the cellular immune response after stimulation of the white blood<br /><br>cells with influenza virus in vitro. The response will be characterized based<br /><br>on; influenza-specific cytokine induction, number of influenza-specific T<br /><br>cells, T cell activation and functional status.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Humoral immune response</p><br>