Evaluation of IMOD effect on oral lichen planus

Phase 3

Conditions: ichen planus.

Registration Number: IRCT138710291559N1

Lead Sponsor: Research center of dental Science of Tehran University of medical sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

clinical histopathologic diagnosis of lichen planus (Lichen planus diagnosis will be made with clinical criteria, consisting of the presence of symmetric reticular or papular lesions with or without erosive/atrophic or Bullous components. Histopathologic features of oral lichen palnus are: 1) Areas of hyperparakeratosis or hyperorthokeratosis, often with a thickening of the granular cell layer and a saw-toothed appearance to the retepages. 2) Liquefaction degeneration or necrosis of the basal layer. 3) A dense subepithelial band, shaped by infiltration of lymphocytes and macrophages. 4) Absence of dysplastic changes)
Exclusion criteria: Any systemic disease, pregnancy and any other mucosal lesions

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical score. Timepoint: 2 weekly in the first month and then monthly for 6 months. Method of measurement: regesteration the primary scores of lesions and their changes on the follow up period as described in the matherial and methods.

Secondary Outcome Measures

Name	Time	Method
Pain and discomfort in the oral lesion. Timepoint: 2 weekly in the first month and then monthly up to 6 month. Method of measurement: VAS scale as described in the matherial and method.