Efficacy and safety of artesunate+ampdiaquine for the treatment of uncomplicated malaria in district hospital of Massakory, Hadjer Lamis region, Chad

Ministry of Health of Chad0 个研究点目标入组 103 人开始时间: 2015年8月26日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•1. age between six months and 5 years;
•2. mono-infection with P. falciparum detected by microscopy;
•3. parasitaemia of 1000–100,000/microliter asexual forms;
•4. presence of axillary temperature greater or equal to 37.5 degrees C or history of fever during the past 24 h
•5. ability to swallow oral medication;
•6. ability and willingness to comply with the study protocol for the duration of the study and to comply with the study visit schedule;
•7.informed consent from the parent or guardian in the case of children

•1. presence of general danger signs in children aged under 5 years or signs of severe falciparum malaria according to the definitions of WHO;
•2. weight under 5 kg;
•3. mixed or mono-infection with another Plasmodium species detected by microscopy;
•4. presence of severe malnutrition defined as a child aged 6-60 months has a mid-upper arm circumference belo 115 mm)
•5. presence of febrile conditions due to diseases other than malaria (e.g. measles, acute lower respiratory tract infection, severe diarrhea with dehydration) or other known underlying chronic or severe diseases (e.g. cardiac, renal and hepatic diseases, HIV/AIDS);
•6. regular medication, which may interfere with antimalarial
•pharmacokinetics;
•7. history of hypersensitivity reactions or contraindications to any of the medicine(s) being tested or used as alternative treatment(s);

发起方

Ministry of Health of Chad