In vitro antioxidant activity of Nux vomica 6C and open label randomised clinical trial to evaluate the effectiveness of Nux vomica 6C in comparison with individualised homoeopathic medicines in functional dyspepsia: an integrative study

This research proposal aims to investigate the antioxidant properties of Nux vomica 6c and its clinical effectiveness in treating functional dyspepsia. Nux vomica is a common treatment for functional dyspepsia, particularly for symptoms related to a sedentary lifestyle. Although its therapeutic effectiveness has been established, the scientific understanding of its mechanism of action is limited. Few clinical studies have assessed the efficacy of Nux vomica in functional dyspepsia. Recent pharmacological research suggests that oxidative stress may play a significant role in dyspepsia, and antioxidant remedies may offer therapeutic benefits. However, the antioxidant properties of different Nux vomica potencies have not been thoroughly evaluated in vitro. There is a lack of integrative studies correlating the biochemical actions of Nux vomica with its clinical effects, limiting its validity in evidence-based frameworks. This knowledge gap highlights the need to compare preclinical (in vitro) results with clinical efficacy to validate the use of Nux vomica in functional dyspepsia from both scientific and homoeopathic perspectives. The study has two main components: in vitro assessment of Nux vomica 6c’s antioxidant potential using antioxidant assays and clinical comparison of Nux vomica 6c with individualized homoeopathic medicine in treating functional dyspepsia. A preclinical study followed by an open-label randomized clinical trial will be conducted. The sample size will be 128 patients (64 per group). The primary outcomes will be antioxidant activity of Nux vomica 6c b) Changes in Dyspepsia Symptom Severity Index (DSSI) scores. The secondary outcome will be quality of life changes measured by Short-Form Nepean Dyspepsia Index (SF-NDI). This study aimed to bridge the gap between the traditional use and scientific validity of Nux vomica in treating functional dyspepsia, addressing the lack of integrative studies correlating its biochemical actions with its clinical effects.