A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis

Phase 3

Completed

Conditions: Ulcerative Colitis (UC)

Interventions: Drug: Placebo
Drug: Upadacitinib

Registration Number: NCT03653026

Lead Sponsor: AbbVie

Brief Summary: The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo in inducing clinical remission (per Adapted Mayo score) in participants with moderately to severely active ulcerative colitis (UC).

Detailed Description: Study M14-675 consists of 2 parts, Part 1 and Part 2. Part 1 is a randomized, double-blind, placebo-controlled 8-week induction period. Part 2 is an open-label, 8-week extended treatment period for participants who did not achieve clinical response at Week 8 in Part 1.

Eligible participants are randomized in a 2:1 ratio to one of the two treatment groups (upadacitinib 45 mg or matching placebo) for 8 weeks. The randomization is stratified by biologic inadequate responder (bio-IR) status (bio-IR vs non-bio-IR), corticosteroid use (yes or no), and Adapted Mayo score (≤ 7 or \> 7) at Baseline. Within bio-IR, the randomization is further stratified by number of prior biologic treatments (≤ 1 or \> 1). Within non-bio-IR, the randomization is further stratified by previous biologic use (yes or no).

Participants who achieve clinical response defined by Adapted Mayo Score at Week 8 or Week 16 and do not meet any study discontinuation criteria are eligible to enroll into Study M14-234 Substudy 3 (NCT02819635; 52-week maintenance study) or Study M14-533 Cohort 1 (NCT03006068; long-term follow-up study).

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 522

Inclusion Criteria

Male or female participants ≥ 16 and ≤ 75 years of age at Baseline Note: Adolescent participants at the age of 16 or 17 years old will be eligible to participate if approved by the country or regulatory/health authorities.

Note: Adolescent participants at the age of 16 or 17 years old must weigh ≥ 40 kilograms and meet the definition of Tanner Stage 5 at the Screening Visit.

Diagnosis of Ulcerative Colitis (UC) for 90 days or greater prior to Baseline, confirmed by colonoscopy during the Screening Period, with exclusion of current infection, colonic dysplasia and/or malignancy. Appropriate documentation of biopsy results consistent with the diagnosis of UC, in the assessment of the Investigator, must be available.
Active UC with an Adapted Mayo score of 5 to 9 points and endoscopic subscore of 2 to 3.
Demonstrated an inadequate response, loss of response, or intolerance to at lease one of the following treatments including, oral aminosalicylates, corticosteroids, immunosuppressants, and/or biologic therapies.

Note: Participants who have had inadequate response, loss of response to conventional therapy but have not failed biologic therapy (Non-bio-IR) and have received a prior biologic for up to 1 year may be enrolled, however they must have discontinued the biologic for reasons other than inadequate response or intolerance (e.g., change of insurance, well controlled disease), and must meet criteria for inadequate response, loss of response, or intolerance as defined above.

Female Participants of childbearing potential must have a negative serum pregnancy test at the Screening Visit and a negative urine pregnancy test at the Baseline Visit.
If female, participant must meet the contraception recommendation criteria.

Exclusion Criteria

Participant with current diagnosis of Crohn's disease (CD) or diagnosis of indeterminate colitis (IC).
Current diagnosis of fulminant colitis and/or toxic megacolon.
Participant with disease limited to the rectum (ulcerative proctitis) during the Screening endoscopy.
Received cyclosporine, tacrolimus, mycophenolate mofetil, or thalidomide within 30 days prior to Baseline.
Participant who received azathioprine or 6-mercaptopurine (6-MP) within 10 days of Baseline.
Received intravenous corticosteroids within 14 days prior to Screening or during the Screening Period.
Participant with previous exposure to Janus Activated Kinase (JAK) inhibitor (e.g., tofacitinib, baricitinib, filgotinib, upadacitinib).
Screening laboratory and other analyses show any prespecified abnormal hematologic results.

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	Participants received placebo matching to upadacitinib once daily for 8 weeks. Participants who did not achieve clinical response per Adapted Mayo score at Week 8 received upadacitinib 45 mg once daily for 8 weeks in the open-label extension period.
Upadacitinib 45 mg	Upadacitinib	Participants received 45 mg upadacitinib once daily (QD) for 8 weeks. Participants who did not achieve clinical response per Adapted Mayo score at Week 8 received upadacitinib 45 mg once daily for 8 additional weeks in the open-label extension period.
Placebo	Upadacitinib	Participants received placebo matching to upadacitinib once daily for 8 weeks. Participants who did not achieve clinical response per Adapted Mayo score at Week 8 received upadacitinib 45 mg once daily for 8 weeks in the open-label extension period.

Primary Outcome Measures

Name	Time	Method
Percentage of Participants Who Achieved Clinical Remission Per Adapted Mayo Score at Week 8	Week 8	The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores: 1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal). 2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed). 3. Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration). The overall Adapted Mayo score ranges from 0 to 9 where higher scores represent more severe disease. Clinical remission is defined as an Adapted Mayo score ≤ 2, with SFS ≤ 1 and not higher than Baseline, RBS of 0, and endoscopic subscore ≤ 1.

Secondary Outcome Measures

Name	Time	Method
Percentage of Participants Who Achieved Clinical Response Per Partial Adapted Mayo Score at Week 2	Week 2	The Partial Adapted Mayo Score is a composite score of UC disease activity based on the following 2 subscores: 1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal). 2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed). The overall Partial Adapted Mayo score ranges from 0 to 6 with higher scores representing more severe disease. Clinical response per Partial Adapted Mayo Score is defined as a decrease in Partial Adapted Mayo score ≥ 1 point and ≥ 30% from Baseline, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.
Percentage of Participants Who Reported No Abdominal Pain at Week 8	Week 8	Abdominal pain was assessed by participants in a subject diary completed once a day.
Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 8	Baseline (Week 0) to Week 8	The Inflammatory Bowel Disease Questionnaire (IBDQ) is used to assess health-related quality of life (HRQoL) in patients with ulcerative colitis. It consists of 32 questions evaluating bowel and systemic symptoms, as well as emotional and social functions. Each question is answered on a scale from 1 (worst) to 7 (best). The total score ranges from 32 to 224 with higher scores indicating better health-related quality of life. A positive change from Baseline indicates improvement.
Percentage of Participants With Endoscopic Improvement at Week 8	Week 8	Endoscopic improvement is defined as an endoscopic subscore of 0 or 1. Endoscopies were assessed by a blinded central reader and scored according to the following scale: 0 = Normal or inactive disease; 1 = Mild disease (erythema, decreased vascular pattern); 2 = Moderate disease (marked erythema, lack of vascular pattern, any friability, erosions); 3 = Severe disease (spontaneous bleeding, ulceration).
Percentage of Participants Who Achieved Histologic Improvement at Week 8	Week 8	Histologic improvement is defined as a decrease from Baseline in Geboes score. The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.
Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Score at Week 8	Baseline (Week 0) to Week 8	The FACIT fatigue questionnaire was developed to assess fatigue associated with anemia. It consists of 13 fatigue-related questions. Each question is answered on a 5-point Likert scale: 0 (not at all); 1 (a little bit); 2 (somewhat); 3 (quite a bit); and 4 (very much). The total score ranges from 0 to 52, where higher scores represent less fatigue, and a positive change from Baseline indicates improvement.
Percentage of Participants Who Achieved Clinical Response Per Adapted Mayo Score at Week 8	Week 8	The Adapted Mayo Score is a composite score of UC disease activity based on the following 3 subscores: 1. Stool frequency subscore (SFS), scored from 0 (normal number of stools) to 3 (5 or more stools more than normal). 2. Rectal bleeding subscore (RBS), scored from 0 (no blood seen) to 3 (blood alone passed). 3. Endoscopic subscore, scored from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration). The overall Adapted Mayo score ranges from 0 to 9 with higher scores representing more severe disease. Clinical response per the Adapted Mayo Score is defined as a decrease in Adapted Mayo score ≥ 2 points and ≥ 30% from Baseline, plus a decrease in RBS ≥ 1 or an absolute RBS ≤ 1.
Percentage Of Participants Who Achieved Histologic-Endoscopic Mucosal Improvement at Week 8	Week 8	Histologic endoscopic mucosal improvement is defined as an endoscopic subscore of 0 or 1 and a Geboes score ≤ 3.1. The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration). The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.
Percentage of Participants With Endoscopic Remission at Week 8	Week 8	Endoscopic remission is defined as an endoscopic subscore of 0. Endoscopies were assessed by a blinded central reader and scored according to the following scale: 0 = Normal or inactive disease; 1 = Mild disease (erythema, decreased vascular pattern); 2 = Moderate disease (marked erythema, lack of vascular pattern, any friability, erosions); 3 = Severe disease (spontaneous bleeding, ulceration).
Percentage of Participants Who Reported No Bowel Urgency at Week 8	Week 8	Bowel urgency was assessed by participants in a subject diary completed once a day.
Percentage of Participants Who Achieved Mucosal Healing at Week 8	Week 8	Mucosal healing is defined as an endoscopic score of 0 and Geboes score \< 2.0. The endoscopic subscore ranges from 0 (normal or inactive disease) to 3 (severe disease with spontaneous bleeding, ulceration). The Geboes histologic index includes seven histological features (architectural change, chronic inflammatory infiltrate, lamina propria neutrophils and eosinophils, neutrophils in epithelium, crypt destruction and erosion or ulcers). The Geboes score has 6 grades, each with 3-5 subgrades: Grade 0, structural change only; Grade 1, chronic inflammation; Grade 2, lamina propria neutrophils and eosinophils; Grade 3, neutrophils in epithelium; Grade 4, crypt destruction; and Grade 5, erosions or ulceration.

Trial Locations

Locations (379): TLC Clinical Research Inc /ID# 216831
🇺🇸
Los Angeles, California, United States
Universal Axon Clinical Research /ID# 213462
🇺🇸
Doral, Florida, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 205314
🇺🇸
Los Angeles, California, United States
Next Innovative Clinical Research - Chicago /ID# 217324
🇺🇸
Chicago, Illinois, United States
The University of Chicago Medical Center /ID# 206172
🇺🇸
Chicago, Illinois, United States
The Ohio State University /ID# 205637
🇺🇸
Columbus, Ohio, United States
Optimed Research, Ltd. /ID# 205638
🇺🇸
Columbus, Ohio, United States
Encore Borland-Groover Clinical Research /Id# 208128
🇺🇸
Jacksonville, Florida, United States
United Medical Doctors - Murrieta /ID# 205313
🇺🇸
Murrieta, California, United States
Palmetto Research, LLC /ID# 208293
🇺🇸
Hialeah, Florida, United States
Gastroenterology Center of CT /ID# 208291
🇺🇸
Hamden, Connecticut, United States
Delta Waves, Inc. /ID# 206170
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Colorado Springs, Colorado, United States
East View Medical Research, LLC /ID# 216933
🇺🇸
Mobile, Alabama, United States
Gastro Florida /ID# 206174
🇺🇸
Clearwater, Florida, United States
Citrus Valley Gastroenterology /ID# 205627
🇺🇸
Covina, California, United States
InSite Digestive Health Care - Oxnard /ID# 205628
🇺🇸
Oxnard, California, United States
Inland Empire Clinical Trials, LLC /ID# 216164
🇺🇸
Rialto, California, United States
CB Flock Research Corporation /ID# 206094
🇺🇸
Mobile, Alabama, United States
Gastro Center of Maryland /ID# 206883
🇺🇸
Columbia, Maryland, United States
Western States Clinical Res /ID# 206091
🇺🇸
Wheat Ridge, Colorado, United States
University of Arizona /ID# 208856
🇺🇸
Tucson, Arizona, United States
Moore UC San Diego Cancer Center /ID# 204919
🇺🇸
La Jolla, California, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 216940
🇺🇸
Macon, Georgia, United States
Cfagi Llc /Id# 207995
🇺🇸
Maitland, Florida, United States
Gastro Group of Rochester /ID# 206881
🇺🇸
Rochester, New York, United States
Baylor Scott & White Center for Diagnostic Medicine /ID# 206096
🇺🇸
Temple, Texas, United States
Atlanta Gastroenterology Spec /ID# 206173
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Suwanee, Georgia, United States
Carle Foundation Hospital /ID# 207397
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Effingham, Illinois, United States
Washington Gastroenterology Associates /ID# 206177
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Bellevue, Washington, United States
Premier Medical Group - GI Division /ID# 206097
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Poughkeepsie, New York, United States
NY Scientific /ID# 206080
🇺🇸
Brooklyn, New York, United States
Atrium Health Carolinas Medical Center /ID# 206085
🇺🇸
Charlotte, North Carolina, United States
Dayton Gastroenterology, Inc. /ID# 205639
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Englewood, Ohio, United States
Louisana Research Center, LLC /ID# 206064
🇺🇸
Shreveport, Louisiana, United States
Tri-State Gastroenterology /ID# 206124
🇺🇸
Crestview Hills, Kentucky, United States
Texas Digestive Disease Consultants /ID# 209805
🇺🇸
Cedar Park, Texas, United States
University of Mississippi Medical Center /ID# 213116
🇺🇸
Jackson, Mississippi, United States
Caprock Gastro Research /ID# 215115
🇺🇸
Lubbock, Texas, United States
Charlotte Gastroenterology and Hepatology, PLLC /ID# 206138
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Charlotte, North Carolina, United States
Center for Digestive Health /ID# 207080
🇺🇸
Troy, Michigan, United States
Inquest Clinical Research /ID# 206132
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Baytown, Texas, United States
TX Clinical Research Institute /ID# 206718
🇺🇸
Arlington, Texas, United States
Digestive Health Partners, P.A /ID# 206842
🇺🇸
Asheville, North Carolina, United States
Texas Digestive Disease Consultants /ID# 209948
🇺🇸
Cedar Park, Texas, United States
Guthrie Medical Group, PC /ID# 206078
🇺🇸
Sayre, Pennsylvania, United States
Gastroenterology Associates, P.A. of Greenville /ID# 206098
🇺🇸
Greenville, South Carolina, United States
Great Lakes Gastroenterology Research LLC /ID# 205631
🇺🇸
Mentor, Ohio, United States
Upeclin Fmb - Unesp /Id# 206986
🇧🇷
Botucatu, Sao Paulo, Brazil
Fiona Stanley Hospital /ID# 211642
🇦🇺
Murdoch, Western Australia, Australia
DHAT Research Institute /ID# 206716
🇺🇸
Garland, Texas, United States
Crchum /Id# 207387
🇨🇦
Montreal, Quebec, Canada
CTR Estudios Clinicos /ID# 208036
🇨🇱
Providencia, Chile
Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 205265
🇨🇳
Wuhan, China
Kaiser Clinica e Hospital Dia /ID# 206982
🇧🇷
Sao Jose Do Rio Preto, Sao Paulo, Brazil
St Vincent's Hospital Melbourne /ID# 205758
🇦🇺
Fitzroy, Victoria, Australia
Ctr for Gastrointestinal Healt /ID# 208475
🇺🇸
Franklin, Virginia, United States
Advanced Research Institute /ID# 206133
🇺🇸
Ogden, Utah, United States
Cardio Alem /ID# 211282
🇦🇷
San Isidro, Buenos Aires, Argentina
The Vancouver Clinic, INC. PS /ID# 204973
🇺🇸
Vancouver, Washington, United States
Macquarie University Hospital /ID# 211955
🇦🇺
Macquarie University, New South Wales, Australia
Hepato-Gastroenterologie HK, s.r.o. /ID# 205672
🇨🇿
Hradec Kralove, Czechia
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 206504
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Ribeirão Preto, Sao Paulo, Brazil
Gedyt /ID# 210017
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Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Duplicate_Toronto Digestive Disease Asso /ID# 205498
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Vaughan, Ontario, Canada
Griffith University /ID# 211956
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Southport, Queensland, Australia
Faculdade de Medicina do ABC /ID# 206984
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Santo André, Sao Paulo, Brazil
Corporacion Hospitalaria Juan Cuidad Sede Denominada Hospital Universitario Mayo /ID# 208886
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Bogota DC, Cundinamarca, Colombia
East Tallinn Central Hospital /ID# 207564
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Tallinn, Harjumaa, Estonia
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 206332
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Athens, Greece
Medizinisches Versorgungszentrum Portal 10 /ID# 207137
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Muenster, Germany
Klinicka bolnica Dubrava Zagreb /ID# 208460
🇭🇷
Zagreb, Grad Zagreb, Croatia
Universitatsklinikum Mannheim /ID# 206811
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Mannheim, Baden-Wuerttemberg, Germany
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 206350
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Palermo, Italy
Artroscan s.r.o. /ID# 205668
🇨🇿
Ostrava, Czechia
Duplicate_Praxis am Bayrischen Platz /ID# 206733
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Berlin, Germany
Hospital Universitario San Vic /ID# 208888
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Medellin, Colombia
North Estonia Medical Centre /ID# 207357
🇪🇪
Tallinn, Estonia
Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216223
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Praha, Czechia
CTCenter MaVe s.r.o. /ID# 205671
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Olomouc, Czechia
ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216611
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Rho, Milano, Italy
Gastroenterologische Gemeinschaftspraxis Herne /ID# 214576
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Herne, Nordrhein-Westfalen, Germany
Rambam Health Care Campus /ID# 206362
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Haifa, Israel
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 206347
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Rome, Roma, Italy
A.O.U. Policlinico S.Orsola-Malpighi /ID# 206351
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Bologna, Emilia-Romagna, Italy
Centre Hospitalier Lyon Sud /ID# 209121
🇫🇷
Pierre Benite CEDEX, Rhone, France
Duplicate_General Hospital of Thessaloniki Hippokrateio /ID# 208822
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Thessaloniki, Greece
Nagoya University Hospital /ID# 206355
🇯🇵
Nagoyashi, Aichi, Japan
Ieda Hospital /ID# 207479
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Toyota-shi, Aichi, Japan
Asahikawa Medical University Hospital /ID# 206404
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Midorigaokahiga-shi, Hokkaido, Japan
St. Marianna University School of Medicine Hospital /ID# 209451
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Kawasaki-shi, Kanagawa, Japan
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 206349
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Milan, Italy
Showa University Fujigaoka Hospital /ID# 208224
🇯🇵
Yokohama-shi, Kanagawa, Japan
Tsujinaka Hospital Kashiwanoha /ID# 209573
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Kashiwa-shi, Chiba, Japan
Sameshima Hospital /ID# 207935
🇯🇵
Kagoshima-shi, Kagoshima, Japan
Nagoya City University Hospital /ID# 206058
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Nagoya shi, Aichi, Japan
Yeungnam University Medical Center /ID# 206959
🇰🇷
Daegu, Korea, Republic of
Okayama University Hospital /ID# 217925
🇯🇵
Okayama-shi, Okayama, Japan
Osaka City University Hospital /ID# 206457
🇯🇵
Osaka-shi, Osaka, Japan
Clinresco Centers /ID# 208083
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Johannesburg, Gauteng, South Africa
Hospital Universitario y Politecnico La Fe /ID# 206904
🇪🇸
Valencia, Spain
Pusan National University Hospital /ID# 206956
🇰🇷
Busan, Korea, Republic of
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 209052
🇱🇹
Kaunas, Lithuania
Yamagata University Hospital /ID# 206465
🇯🇵
Yamagata-shi, Yamagata, Japan
Hospital Universitario A Coruna - CHUAC /ID# 206907
🇪🇸
A Coruna, Spain
Hospital Clinic de Barcelona /ID# 206906
🇪🇸
Barcelona, Spain
Yonsei University Health System, Severance hospital /ID# 206958
🇰🇷
Seoul, Korea, Republic of
Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 208082
🇿🇦
Johannesburg, Gauteng, South Africa
Hospital Clinico Universitario de Salamanca /ID# 205013
🇪🇸
Salamanca, Spain
Umraniye Training and Res Hosp /ID# 208206
🇹🇷
Istanbul, Turkey
Lenasia Clinical Trial Centre /ID# 214359
🇿🇦
Johannesburg, Gauteng, South Africa
Hospital Universitario Ramon y Cajal /ID# 204410
🇪🇸
Madrid, Spain
Hospital Universitario La Paz /ID# 214540
🇪🇸
Madrid, Spain
Kyiv Regional Hospital /ID# 217373
🇺🇦
Kyiv, Kyivska Oblast, Ukraine
Medical centre of CONSILIUM MEDICAL LLC /ID# 217447
🇺🇦
Kyiv, Ukraine
MD Search /ID# 208084
🇿🇦
Boksburg North, Gauteng, South Africa
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 207507
🇹🇷
Istanbul, Turkey
Basingstoke & North Hampshire /ID# 207985
🇬🇧
Basingstoke, United Kingdom
Gazi University Med. Faculty /ID# 208040
🇹🇷
Ankara GAZI, Turkey
Huddersfield Royal Infirmary /ID# 217660
🇬🇧
Huddersfield, United Kingdom
Hospital Universitario Reina Sofia /ID# 204412
🇪🇸
Cordoba, Spain
Inselspital, Universitaetsklinik /ID# 211312
🇨🇭
Bern, Switzerland
Mersin University Medical /ID# 208039
🇹🇷
Mersin, Turkey
Queen Elizabeth University Hos /ID# 205154
🇬🇧
Glasgow, United Kingdom
Barts and the London NHS Trust /ID# 205153
🇬🇧
Whitechapel, United Kingdom
University of Miami /ID# 215445
🇺🇸
Miami, Florida, United States
Coral Research Clinic /ID# 208292
🇺🇸
Miami, Florida, United States
Indianapolis Gastroenterology /ID# 206381
🇺🇸
Indianapolis, Indiana, United States
Vilo Research Group Inc /ID# 212625
🇺🇸
Houston, Texas, United States
Baylor College of Medicine - Baylor Medical Center /ID# 206717
🇺🇸
Houston, Texas, United States
GI Specialists of Houston /ID# 206090
🇺🇸
Houston, Texas, United States
Centex Studies, Inc. - Houston /ID# 206168
🇺🇸
Houston, Texas, United States
San Diego Clinical Trials /ID# 212122
🇺🇸
San Diego, California, United States
Medical Assoc Research Grp /ID# 205626
🇺🇸
San Diego, California, United States
University of Cincinnati /ID# 205633
🇺🇸
Cincinnati, Ohio, United States
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 205333
🇨🇳
Shanghai, Shanghai, China
The First Affiliated Hospital of Nanchang University /ID# 212186
🇨🇳
Nanchang, Jiangxi, China
The First Hospital of Jilin University /ID# 210088
🇨🇳
Changchun, Jilin, China
West China Hospital, Sichuan University /ID# 205332
🇨🇳
Chengdu, China
Sun Yat-sen Memorial Hospital of Sun Yat-sen University /ID# 205267
🇨🇳
Guangzhou, Guangdong, China
The Sixth Affiliated Hosp Sun /ID# 205268
🇨🇳
Guangzhou, Guangdong, China
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 205271
🇨🇳
Hangzhou, Zhejiang, China
Duplicate_Tianjin Med Univ General Hosp /ID# 205246
🇨🇳
Tianjin, China
Care Access Research /ID# 217003
🇺🇸
Huntington Beach, California, United States
United Medical Doctors /ID# 207867
🇺🇸
Los Alamitos, California, United States
Facey Medical Foundation /ID# 205301
🇺🇸
Mission Hills, California, United States
Western Connecticut Medical Group /ID# 208290
🇺🇸
Danbury, Connecticut, United States
Infinite Clinical Trials /ID# 215343
🇺🇸
Riverdale, Georgia, United States
MediSphere Medical Research Center /ID# 206073
🇺🇸
Evansville, Indiana, United States
University of Iowa Hospitals and Clinics /ID# 206167
🇺🇸
Iowa City, Iowa, United States
Clin Res Inst of Michigan, LLC /ID# 207078
🇺🇸
Chesterfield, Michigan, United States
Revival Research Institute, LLC /ID# 207282
🇺🇸
Southfield, Michigan, United States
NYU Langone Long Island Clinical Research Associates /ID# 206079
🇺🇸
Lake Success, New York, United States
Richmond University Medical Center /ID# 213185
🇺🇸
Staten Island, New York, United States
Hometown Urgent Care and Resea /ID# 205630
🇺🇸
Dayton, Ohio, United States
Options Health Research, LLC /ID# 206707
🇺🇸
Tulsa, Oklahoma, United States
Gastro One /ID# 206178
🇺🇸
Germantown, Tennessee, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 207484
🇺🇸
Dallas, Texas, United States
Duplicate_Tyler Research Institue /ID# 206075
🇺🇸
Tyler, Texas, United States
Gastro Health & Nutrition - Victoria /ID# 205378
🇺🇸
Victoria, Texas, United States
Virginia Mason - Seattle Orthapedics /ID# 206070
🇺🇸
Seattle, Washington, United States
Hospital Britanico de Buenos Aires /ID# 209497
🇦🇷
Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Duplicate_Mater Misericordiae /ID# 212687
🇦🇺
South Brisbane, Queensland, Australia
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 206354
🇮🇹
Negrar, Verona, Italy
Hospital de Clinicas de Porto Alegre /ID# 206985
🇧🇷
Porto Alegre, Rio Grande Do Sul, Brazil
Cotton-O'Neil Clinical Res Ctr /ID# 206175
🇺🇸
Topeka, Kansas, United States
Duplicate_Plains Clinical Research Center, LLC /ID# 205111
🇺🇸
Fargo, North Dakota, United States
Morales Vargas Centro de Investigacion S.C. /ID# 211326
🇲🇽
Leon, Guanajuato, Mexico
University Clinical Centre of the Republic of Srpska /ID# 208053
🇧🇦
Banja Luka, Republika Srpska, Bosnia and Herzegovina
University of Calgary - Cumming School of Medicine - Adult Cystic Fibrosis Clini /ID# 205755
🇨🇦
Calgary, Alberta, Canada
Research Group /ID# 208037
🇨🇱
Santiago, Region Metropolitana De Santiago, Chile
Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216406
🇨🇳
Shiyan, Hubei, China
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 205266
🇨🇳
Wuhan, Hubei, China
Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 208887
🇨🇴
Monteria, Cordoba, Colombia
Nemocnice Pardubickeho kraje, a.s. /ID# 213540
🇨🇿
Pardubice, Czechia
Axon Clinical, s.r.o. /ID# 205670
🇨🇿
Praha, Czechia
Laakarikeskus Ikioma /ID# 205814
🇫🇮
Mikkeli, Finland
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215813
🇩🇪
Saarbrücken, Saarland, Germany
Saiseikai Fukuoka Genaral Hospital /ID# 209482
🇯🇵
Fukuoka-shi, Fukuoka, Japan
Sapporo Higashi Tokushukai Hospital /ID# 208494
🇯🇵
Sapporo-shi, Hokkaido, Japan
Sapporo Tokushukai Hospital /ID# 209448
🇯🇵
Sapporo-shi, Hokkaido, Japan
Kanazawa University Hospital /ID# 206316
🇯🇵
Kanazawa-shi, Ishikawa, Japan
Aoyama Clinic /ID# 206452
🇯🇵
Kobe-shi, Hyogo, Japan
Iwate Medical University Uchimaru Medical Center /ID# 207051
🇯🇵
Morioka-shi, Iwate, Japan
Japanese Red Cross Osaka Hospital /ID# 209478
🇯🇵
Osaka-shi, Osaka, Japan
St.Luke's International Hospital /ID# 208076
🇯🇵
Chuo-ku, Tokyo, Japan
Shoyukai Fujita Gastroenterological Hospital /ID# 216493
🇯🇵
Takatsuki-shi, Japan
Kangbuk Samsung Hospital /ID# 206960
🇰🇷
Seoul, Seoul Teugbyeolsi, Korea, Republic of
Dong-A University Hospital /ID# 206955
🇰🇷
Busan, Korea, Republic of
Duplicate_CHA Bundang Medical Center /ID# 207432
🇰🇷
Seongnam-si, Gyeonggi-do, Korea, Republic of
Centrum Medyczne Reuma Park w Warszawie /ID# 212913
🇵🇱
Warsaw, Mazowieckie, Poland
Gastromed /Id# 216108
🇵🇱
Torun, Kujawsko-pomorskie, Poland
Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 206117
🇵🇹
Lisboa, Portugal
Hospital Santo Antonio dos Cap /ID# 206145
🇵🇹
Lisbon, Portugal
NW State Medical Univ na Mechn /ID# 208258
🇷🇺
St. Petersburg, Leningradskaya Oblast, Russian Federation
Medak s.r.o. /ID# 205191
🇸🇰
Bratislava, Bratislavsky Kraj, Slovakia
Wits Clinical Research Site /ID# 208949
🇿🇦
Johannesburg, Gauteng, South Africa
Private Practice Dr MN Rajabally /ID# 205273
🇿🇦
Cape Town, Western Cape, South Africa
Hospital Unversitario Marques de Valdecilla /ID# 216622
🇪🇸
Santander, Cantabria, Spain
East Tennessee Research Institute /ID# 206169
🇺🇸
Johnson City, Tennessee, United States
Arizona Arthritis & Rheumatology Research, PLLC /ID# 211030
🇺🇸
Sun City, Arizona, United States
Southern Therapy and Advanced Research (STAR) LLC /ID# 206069
🇺🇸
Jackson, Mississippi, United States
Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211887
🇺🇸
Tempe, Arizona, United States
Mautalen Salud e Investigacion /ID# 206033
🇦🇷
Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma De Buenos Aires, Argentina
Shaare Zedek Medical Center /ID# 206365
🇮🇱
Jerusalem, Israel
Toho University Medical Center Sakura Hospital /ID# 207705
🇯🇵
Sakura-shi, Chiba, Japan
Tampere University Hospital /ID# 206161
🇫🇮
Tampere, Pirkanmaa, Finland
Percuro Clinical Research, Ltd /ID# 205501
🇨🇦
Victoria, British Columbia, Canada
Atlantic Digestive Health Inst /ID# 208748
🇺🇸
Morristown, New Jersey, United States
Houma Digestive Health Special /ID# 206176
🇺🇸
Houma, Louisiana, United States
Semmelweis Egyetem /ID# 205883
🇭🇺
Budapest, Hungary
Las Vegas Medical Research /ID# 206814
🇺🇸
Las Vegas, Nevada, United States
AGA Clinical Research Associates, LLC /ID# 206880
🇺🇸
Egg Harbor Township, New Jersey, United States
Monash Medical Centre /ID# 206486
🇦🇺
Melbourne, Victoria, Australia
Hospital Privado Univesitario /ID# 206030
🇦🇷
Cordoba, Argentina
Klinik Landstrasse /ID# 205764
🇦🇹
Vienna, Wien, Austria
University Clinical Centre of the Republic of Srpska /ID# 208055
🇧🇦
Banja Luka, Republika Srpska, Bosnia and Herzegovina
Medical University of Vienna /ID# 205763
🇦🇹
Vienna, Wien, Austria
Universitair Ziekenhuis Leuven /ID# 205988
🇧🇪
Leuven, Vlaams-Brabant, Belgium
University Clinical Hospital Mostar /ID# 208054
🇧🇦
Mostar, Bosnia and Herzegovina
LKH Salzburg and Paracelsus /ID# 208788
🇦🇹
Salzburg, Austria
AZ Maria Middelares /ID# 210928
🇧🇪
Gent, Belgium
Hospital Guillermo Grant Benavente de Concepción /ID# 212426
🇨🇱
Concepción, Chile
Hospital Clinico Universidad De Los Andes /ID# 207426
🇨🇱
Santiago, Chile
University Clinical Center Tuzla /ID# 208057
🇧🇦
Tuzla, Tuzlanski, Bosnia and Herzegovina
Clinical Center University of Sarajevo /ID# 208058
🇧🇦
Sarajevo, Bosnia and Herzegovina
CIUSSS de l'Estrie - CHUS /ID# 205499
🇨🇦
Sherbrooke, Quebec, Canada
M y F Estudios Clínicos Ltda. /ID# 208035
🇨🇱
Santiago, Region Metropolitana De Santiago, Chile
Poliklinika Solmed /ID# 211568
🇭🇷
Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Rijeka /ID# 208650
🇭🇷
Rijeka, Primorsko-goranska Zupanija, Croatia
Klinicki bolnicki centar Split /ID# 217027
🇭🇷
Split, Croatia
West Tallinn Central Hospital /ID# 207356
🇪🇪
Tallinn, Estonia
Keski-Suomen Sairaala Nova /ID# 206159
🇫🇮
Jyvaskyla, Finland
Tartu University Hospital /ID# 212282
🇪🇪
Tartu, Estonia
Chu de Nice-Hopital L'Archet Ii /Id# 209118
🇫🇷
Nice CEDEX 3, Alpes-Maritimes, France
Tyks /Id# 205813
🇫🇮
Turku, Finland
General Hospital of Athens Laiko /ID# 208671
🇬🇷
Athens, Attiki, Greece
Beaumont Hospital /ID# 206509
🇮🇪
Dublin, Ireland
University General Hospital of Heraklion PA.G.N.I /ID# 207061
🇬🇷
Heraklion, Kriti, Greece
University Hospital Galway /ID# 218035
🇮🇪
Galway, Ireland
Bekes Megyei Kozponti Korhaz /ID# 205885
🇭🇺
Bekescsaba, Hungary
Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 207992
🇭🇺
Sopron, Hungary
Toyohashi Municipal Hospital /ID# 207625
🇯🇵
Toyohashi-shi, Aichi, Japan
Hirosaki National Hospital /ID# 206387
🇯🇵
Hirosaki-shi, Aomori, Japan
Tokatsu Tsujinaka Hospital /ID# 214963
🇯🇵
Abiko-shi, Chiba, Japan
Mentahaz Maganorvosi Kozpont /ID# 205882
🇭🇺
Szekesfehervar, Hungary
Juntendo University Urayasu Hospital /ID# 208784
🇯🇵
Urayasu-shi, Chiba, Japan
Kurume University Hospital /ID# 206385
🇯🇵
Kurume-shi, Fukuoka, Japan
NHO Fukuyama Medical Center /ID# 206295
🇯🇵
Fukuyama-shi, Hiroshima, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 206059
🇯🇵
Sapporo-shi, Hokkaido, Japan
Sapporo Medical University Hospital /ID# 206314
🇯🇵
Sapporo-shi, Hokkaido, Japan
Yokkaichi Hazu Medical Center /ID# 214348
🇯🇵
Yokkaichi-shi, Mie, Japan
Kyoto University Hospital /ID# 211809
🇯🇵
Kyoto-shi, Kyoto, Japan
Fukui Prefectural Hospital /ID# 210449
🇯🇵
Fukui-shi, Fukui, Japan
Kenseikai Dongo Hospital /ID# 208101
🇯🇵
Yamatotakada-shi, Nara, Japan
Niigata University Medical & Dental Hospital /ID# 218049
🇯🇵
Niigata-shi, Niigata, Japan
Ishida Clinic of IBD and Gastroenterology /ID# 210119
🇯🇵
Oita-shi, Oita, Japan
Fukuoka University Chikushi Hospital /ID# 214405
🇯🇵
Chikushino-shi, Fukuoka, Japan
Ogaki Municipal Hospital /ID# 208227
🇯🇵
Ogaki-shi, Gifu, Japan
Hiroshima University Hospital /ID# 206464
🇯🇵
Hiroshima-shi, Hiroshima, Japan
Obihiro kosei Hospital /ID# 210424
🇯🇵
Obihiro-shi, Hokkaido, Japan
Idzuro Imamura Hospital /ID# 207639
🇯🇵
Kagoshima-shi, Kagoshima, Japan
NHO Nagasaki Medical Center /ID# 210822
🇯🇵
Omura-shi, Nagasaki, Japan
Hyogo College of Medicine Hospital /ID# 206455
🇯🇵
Nishinomiya-shi, Hyogo, Japan
Mie University Hospital /ID# 206803
🇯🇵
Tsu-shi, Mie, Japan
Center Hospital of the National Center for Global Health and Medicine /ID# 209532
🇯🇵
Shinjuku-ku, Tokyo, Japan
National Hospital Organization Sendai Medical Center /ID# 209528
🇯🇵
Sendai-shi, Miyagi, Japan
Saiseikai Niigata Hospital /ID# 209921
🇯🇵
Niigata-shi, Niigata, Japan
Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 206646
🇯🇵
Kurashiki-shi, Okayama, Japan
Toyonaka Municipal Hospital /ID# 217082
🇯🇵
Toyonaka-shi, Osaka, Japan
Kinshukai Infusion Clinic /ID# 207865
🇯🇵
Osaka-shi, Osaka, Japan
Kitano Hospital /ID# 210397
🇯🇵
Osaka-shi, Osaka, Japan
Saitama Medical Center /ID# 206393
🇯🇵
Kawagoe-shi, Saitama, Japan
Tokitokai Tokito clinic /ID# 206313
🇯🇵
Saitama-shi, Saitama, Japan
National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210710
🇯🇵
Higashi-ohmi-shi, Shiga, Japan
Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 208067
🇲🇽
Monterrey, Nuevo Leon, Mexico
Universitetssykehuset Nord-Norge /ID# 205691
🇳🇴
Tromsø, Troms, Norway
Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215070
🇵🇱
Warszawa, Mazowieckie, Poland
Saga University Hospital /ID# 209270
🇯🇵
Saga-shi, Saga, Japan
Shimane University School of Medicine /ID# 208905
🇯🇵
Izumo-shi, Shimane, Japan
Tokyo Medical And Dental University, Medical Hospital /ID# 206453
🇯🇵
Bunkyo-ku, Tokyo, Japan
Endoskopia Sp. z o.o. /ID# 212964
🇵🇱
Sopot, Pomorskie, Poland
Euromedservice /ID# 208265
🇷🇺
Pushkin, Russian Federation
LLC Novaya Clinica /ID# 208260
🇷🇺
Pyatigorsk, Russian Federation
Clin Hosp Ctr Bezanijska Kosa /ID# 206413
🇷🇸
Belgrade, Beograd, Serbia
University Clinical Center Kragujevac /ID# 206410
🇷🇸
Kragujevac, Sumadijski Okrug, Serbia
Taipei Veterans General Hosp /ID# 207849
🇨🇳
Taipei City, Taiwan
Hamamatsu University Hospital /ID# 206459
🇯🇵
Hamamatsu-shi, Shizuoka, Japan
NHO Shizuoka Medical Center /ID# 208785
🇯🇵
Sunto-gun, Shizuoka, Japan
P. Stradins Clinical Univ Hosp /ID# 206827
🇱🇻
Riga, Latvia
Klaipeda Seamens Hospital /ID# 208791
🇱🇹
Klaipeda, Lithuania
Vilnius University Hospital /ID# 209051
🇱🇹
Vilnius, Lithuania
Centro Hospitalar de Entre Douro e Vouga /ID# 205563
🇵🇹
Santa Maria Da Feira, Porto, Portugal
Tokyo Women's Medical University Hospital /ID# 206460
🇯🇵
Shinjuku-ku, Tokyo, Japan
Teikyo University Hospital /ID# 209866
🇯🇵
Itabashi-ku, Tokyo, Japan
Tokai University Hachioji Hospital /ID# 208903
🇯🇵
Hachioji-shi, Tokyo, Japan
Tokuyama Central Hospital /ID# 216994
🇯🇵
Shunan-shi, Yamaguchi, Japan
Riga East Clinical Univ Hosp /ID# 206828
🇱🇻
Riga, Latvia
Klaipeda University Hospital /ID# 208790
🇱🇹
Klaipeda, Lithuania
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 207662
🇲🇾
Kuala Lumpur, Selangor, Malaysia
Erasmus Medisch Centrum /ID# 205280
🇳🇱
Rotterdam, Netherlands
Akershus Universitetssykehus_MAIN /ID# 205293
🇳🇴
Lorenskog, Akershus, Norway
Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 205556
🇵🇹
Ponte de Lima, Viana Do Castelo, Portugal
Duplicate_Uni Malaya MC /ID# 208936
🇲🇾
Kuala Lumpur, Malaysia
NZOZ Vivamed /ID# 216697
🇵🇱
Warszawa, Mazowieckie, Poland
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 211652
🇷🇺
Stavropol, Stavropol Skiy Kray, Russian Federation
University Clinical Center Serbia /ID# 205256
🇷🇸
Belgrade, Beograd, Serbia
Centrum Zdrowia MDM /ID# 205874
🇵🇱
Warszawa, Mazowieckie, Poland
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 205554
🇵🇹
Guimaraes, Braga, Portugal
Hospital Garcia de Orta, EPE /ID# 206143
🇵🇹
Almada, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 206142
🇵🇹
Porto, Portugal
CCA Braga - Hospital de Braga /ID# 206144
🇵🇹
Braga, Portugal
Immanuel Kant Baltic Federal University /ID# 208264
🇷🇺
Kaliningrad, Kaliningradskaya Oblast, Russian Federation
Perm Clinical Center of the Federal Medical and Biological Agency /ID# 211653
🇷🇺
Perm, Permskiy Kray, Russian Federation
School of Medicine University of Puerto Rico-Medical Science Campus /ID# 209626
🇵🇷
San Juan, Puerto Rico
Medical Company Hepatolog /ID# 208261
🇷🇺
Samara, Samarskaya Oblast, Russian Federation
Kazan State Medical University /ID# 208256
🇷🇺
Kazan, Tatarstan, Respublika, Russian Federation
Olla-Med Clinic /ID# 215335
🇷🇺
Moscow, Russian Federation
Republican hospital named after V.A. Baranov /ID# 206507
🇷🇺
Petrozavodsk, Russian Federation
Clinical Hosp Center Zvezdara /ID# 205258
🇷🇸
Belgrade, Beograd, Serbia
Military Medical Academy /ID# 205257
🇷🇸
Belgrade, Beograd, Serbia
General Hospital Leskovac /ID# 217881
🇷🇸
Leskovac, Serbia
Tan Tock Seng Hospital /ID# 207663
🇸🇬
Singapore, Singapore
GASTRO I., s.r.o. /ID# 205148
🇸🇰
Presov, Slovakia
Clinical Center Vojvodina /ID# 205259
🇷🇸
Novi Sad, Vojvodina, Serbia
Hospital Universitario Dr. Negrin /ID# 206905
🇪🇸
Las Palmas de Gran Canaria, Las Palmas, Spain
Communal Non-Commercial Enterprize of Kharkiv Regional Council Regional Clinical /ID# 206939
🇺🇦
Kharkiv, Kharkivska Oblast, Ukraine
University Clinical Center of Nis /ID# 206411
🇷🇸
NIS, Nisavski Okrug, Serbia
Fakultna nemocnica s poliklini /ID# 211372
🇸🇰
Nove Zamky, Slovakia
Universitaetsspital Zuerich /ID# 211308
🇨🇭
Zurich, Switzerland
National University Hospital /ID# 209099
🇸🇬
Singapore, Singapore
Gleneagles Medical Centre /ID# 206954
🇸🇬
Singapore, Singapore
B+B MED, s.r.o. /ID# 205213
🇸🇰
Kosice, Slovakia
National Taiwan University Hospital /ID# 207847
🇨🇳
Taipei City, Taipei, Taiwan
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 205147
🇸🇰
Banska Bystrica, Slovakia
Kantonsspital St. Gallen /ID# 211310
🇨🇭
St. Gallen, Sankt Gallen, Switzerland
Mediclinic Milnerton /ID# 207979
🇿🇦
CAPE TOWN Milnerton, Western Cape, South Africa
Kingsbury Hospital /ID# 205281
🇿🇦
Cape Town, Western Cape, South Africa
Universitaetsspital Basel /ID# 211381
🇨🇭
Basel, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 207848
🇨🇳
Kaohsiung, Taiwan
China Medical University Hosp /ID# 207845
🇨🇳
Taichung City, Taichung, Taiwan
Erciyes University Medical Fac /ID# 207506
🇹🇷
Melikgazi, Kayseri, Turkey
PE PMC Acinus, Medical and Diagnostic Center /ID# 217218
🇺🇦
Kropyvnytskyi, Ukraine
Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 216300
🇺🇦
Vinnytsia, Ukraine
Istituto Clinico Humanitas /ID# 206346
🇮🇹
Rozzano, Milano, Italy
Hospital Nossa Senhora das Graças /ID# 206981
🇧🇷
Curitiba, Parana, Brazil
Mayo Clinic /ID# 205645
🇺🇸
Rochester, Minnesota, United States
Hightower Clinical /ID# 216336
🇺🇸
Oklahoma City, Oklahoma, United States
Digestive Disease Specialists /ID# 206076
🇺🇸
Oklahoma City, Oklahoma, United States
Quality Medical Research /ID# 206088
🇺🇸
Nashville, Tennessee, United States
Vanderbilt University Medical Center /ID# 210405
🇺🇸
Nashville, Tennessee, United States
Southern Star Research Institute, LLC /ID# 205379
🇺🇸
San Antonio, Texas, United States
Froedtert Memorial Lutheran Hospital /ID# 206945
🇺🇸
Milwaukee, Wisconsin, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 206710
🇺🇸
San Antonio, Texas, United States
Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 206917
🇺🇸
Milwaukee, Wisconsin, United States
Hospital Clínico Universitario de Santiago-CHUS /ID# 204411
🇪🇸
Santiago de Compostela, A Coruna, Spain
Agaplesion Markus Krankenhaus /ID# 206731
🇩🇪
Frankfurt am Main, Germany
Duplicate_Universitaetsklinikum Tuebingen /ID# 206737
🇩🇪
Tübingen, Baden-Wuerttemberg, Germany
Duplicate_Univ Hosp Schleswig-Holstein /ID# 206791
🇩🇪
Kiel, Germany
ISCARE a.s. /ID# 209240
🇨🇿
Praha, Czechia
DiGiovanna Institute for Medical Education & Research /ID# 206885
🇺🇸
North Massapequa, New York, United States
Advanced Research Institute, Inc /ID# 206077
🇺🇸
New Port Richey, Florida, United States
Nature Coast Clinical Research - Inverness /ID# 206087
🇺🇸
Inverness, Florida, United States
Healthcare Research Consultant /ID# 206706
🇺🇸
Tulsa, Oklahoma, United States
Rutgers Robert Wood Johnson /ID# 207382
🇺🇸
New Brunswick, New Jersey, United States
Endoscopic Research, Inc. /ID# 207360
🇺🇸
Orlando, Florida, United States
AdventHealth Tampa /ID# 207363
🇺🇸
Tampa, Florida, United States
Huron Gastroenterology Assoc /ID# 205109
🇺🇸
Ann Arbor, Michigan, United States
Omega Research Consultants /ID# 206066
🇺🇸
Orlando, Florida, United States
Clinical Research Trials of Florida, Inc. /ID# 206068
🇺🇸
Tampa, Florida, United States
University of South Florida /ID# 214495
🇺🇸
Tampa, Florida, United States
University of Michigan Health Systems /ID# 206918
🇺🇸
Ann Arbor, Michigan, United States
Pharmacorp Clinical Trials /ID# 206074
🇺🇸
Charleston, South Carolina, United States
Wake Forest Baptist Medical Center /ID# 206067
🇺🇸
Winston-Salem, North Carolina, United States
University of New Mexico Department of Internal Medicine /ID# 214397
🇺🇸
Albuquerque, New Mexico, United States
Advantage Clinical Trials /ID# 206082
🇺🇸
Bronx, New York, United States
Allen Whey Khye Lim Professional Corporation /ID# 211167
🇨🇦
Edmonton, Alberta, Canada
Covenant Health /ID# 205500
🇨🇦
Edmonton, Alberta, Canada
Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 208068
🇲🇽
Guadalajara, Jalisco, Mexico
St. George's Healthcare NHS /ID# 208375
🇬🇧
London, United Kingdom