Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine in Major Abdominal Cancer Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- time to first analgesic request
研究概览
简要总结
Duloxetine is a serotonin-norepinephrine reuptake inhibitor primarily used for treatment of major depression and anxiety. Duloxetine also has been used in the treatment of chronic pain conditions, such as osteoarthritis and musculoskeletal pain. There are few studies examining its effect for acute pain. The objective of this study is to evaluate the analgesic effect of duloxetine combined with intrathecal morphine for patients subjected to major abdominal cancer surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients, subjected to major abdominal cancer surgery
排除标准
- •patients on chronic opioid therapy
- •patients allergic to study drugs (duloxetine+morphine)
- •patients have uncontrolled hypertension and or ischemic heart disease
研究组 & 干预措施
duloxetine+morphine
干预措施: Duloxetine 60mg (Drug)
placebo+morphine
干预措施: placebo (Drug)
结局指标
主要结局
time to first analgesic request
时间窗: 48 hours postoperatively
the time elapsed from (0 hour = immediately postoperative) to time of first demand to analgesic
次要结局
未报告次要终点
研究者
Diab Fuad Hetta
lecturer of anesthesia and pain management , Assuit university
Assiut University