Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine

Not Applicable

Completed

• Conditions: Acute Pain
• Interventions: Drug: Duloxetine 60mg; Drug: placebo

• Registration Number: NCT03560427
• Lead Sponsor: Assiut University

Brief Summary

Duloxetine is a serotonin-norepinephrine reuptake inhibitor primarily used for treatment of major depression and anxiety. Duloxetine also has been used in the treatment of chronic pain conditions, such as osteoarthritis and musculoskeletal pain. There are few studies examining its effect for acute pain. The objective of this study is to evaluate the analgesic effect of duloxetine combined with intrathecal morphine for patients subjected to major abdominal cancer surgery

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-05-19
• Study First Submitted QC: 2018-06-06
• Study First Posted: 2018-06-18
• Study Start: 2018-09-10
• Status Verified: 2020-03
• Primary Completion: 2020-03-10
• Study Completion: 2020-03-14
• Last Update Submitted: 2020-03-16
• Last Update Posted: 2020-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• adult patients, subjected to major abdominal cancer surgery

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Exclusion Criteria

• patients on chronic opioid therapy
• patients allergic to study drugs (duloxetine+morphine)
• patients have uncontrolled hypertension and or ischemic heart disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
duloxetine+morphine	Duloxetine 60mg	-
placebo+morphine	placebo	-

Primary Outcome Measures

Name	Time	Method
time to first analgesic request	48 hours postoperatively	the time elapsed from (0 hour = immediately postoperative) to time of first demand to analgesic

Trial Locations

Locations (1)

Diab; 🇪🇬 Assiut, Assuit, Egypt