A Pilot, Randomised, Unblinded, Feasibility, Safety and Biochemical and Physiological Efficacy Study of Targeted Mild Therapeutic Hypercapnia in Patients Undergoing Cardiopulmonary Bypass

Austin Health0 个研究点目标入组 31 人开始时间: 2016年2月2日最近更新: 2020年1月13日

适应症

试验速览

阶段: 未知
状态: 已完成
发起方: Austin Health
入组人数: 31

研究概览研究设计入排标准研究者记录与标识符相似试验

研究概览

简要总结

Trend towards benefit of targeted mild therapeutic hypercapnia (slightly higher than normal targeting of blood carbon dioxide level) on cerebral oxygenation during cardiopulmonary bypass; non-inferior safety outcomes of intervention; finding of ongoing cerebral oxygen desaturation post-operatively across both intervention & control groups.

研究设计

研究类型: Interventional
分配方式: Randomised controlled trial
主要目的: Prevention
盲法: Open (masking not used)

入排标准

年龄范围: 18 Years 至 o limit（—）
性别: All

入选标准

•1. Admitted to the Austin Hospital for elective cardiac surgery
•2. Aged 18 years or older
•3. Able to speak and read English

排除标准

•1. Pre-operative Mini-Mental State Examination score < 24
•2. Emergency cases
•3. History of neuropsychiatric disorders
•4. Contraindications to increased CO2 levels, such as right-sided heart failure, pulmonary hypertension, metabolic acidosis
•5. Aortic arch surgery

研究者

发起方

Austin Health

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