Evaluation the effect of prolonging the duration of administration of Colistin infusion on the Colistin-induced nephrotoxicity
Phase 2
Recruiting
- Conditions
- ephrotoxicity.
- Registration Number
- IRCT20230225057533N1
- Lead Sponsor
- Arak University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
At least 18 years old
Infection with Multidrug resistance organism
Sputum culture be positive with Acinetobacter baumannii , Klebsiella pneumoniae
Exclusion Criteria
Discontinue treatment with colistin
Receiving other nephrotoxic drugs at the same time
Oliguria (urine output less than 500 cc in 24 hours)
Hypotension due to a reason other than sepsis (embolism, MI, hypovolemic shock),
receiving NSAIDs
Receive albumin
receiving contrast agents
Estimated glomerular filtration rate (eGFR) less than 5 mL/min/1.73 m2
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method evel ofCreatinine and BUN. Timepoint: Daily. Method of measurement: Blood test.
- Secondary Outcome Measures
Name Time Method