HYVET 2: treatment of white coat hypertension in the very elderly
- Conditions
- White coat hypertensionCirculatory SystemElevated blood-pressure reading, without diagnosis of hypertension
- Registration Number
- ISRCTN13127656
- Lead Sponsor
- niversity of Sussex
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 100
1. Patients =75 years of age
2. Clinic sitting systolic BP =150 mmHg but <200 mmHg and diastolic BP <110 mmHg
3. Established diagnosis of white coat hypertension - confirmed if the mean ambulatory day time average systolic BP is <135 mmHg and diastolic BP is <85 mmHg (from at least 14 measurements) or for HBPM from BP readings twice a day for at least 5 days (ideally 7 days) at baseline
4. Not taken antihypertensive drug therapy within the last 6 months
5. Capacity to consent
6. Provision of documented informed consent
7. Ability to comply with the protocol and additional study visits and assessments
1. Contraindication to the use of indapamide MR and perindopril in accordance with the summary of product characteristics
2. Regular non-steroidal anti-inflammatory drug (NSAID) use. Regular use being defined by the local GP with consideration to cardiovascular risk and blood pressure
3. Hypertensive emergency
4. Secondary hypertension
5. Postural hypotension (postural drop in systolic BP> = 20 mmHg or postural symptoms at screening)
6. Any stroke or myocardial infarction in the previous 6 months
7. Heart failure requiring treatment with drugs having an antihypertensive effect
8. Previous documented evidence of gout
9. eGFR less than 30ml/min
10. Montreal cognitive assessment score (MoCA) < 22
11. Life expectancy < 1 year due to malignancy or chronic disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method