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Clinical Trials/NCT04012632
NCT04012632
Completed
Not Applicable

Polymorphisms in the Kisspeptin/GPR54 Pathway Genes and the Risk of Early Puberty

Shenzhen Center for Disease Control and Prevention0 sites628 target enrollmentSeptember 1, 2016
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ConditionsPuberty, Precocious

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Puberty, Precocious
Sponsor
Shenzhen Center for Disease Control and Prevention
Enrollment
628
Primary Endpoint
the polymorphism in the KISS1/GPR54 pathway genes
Status
Completed
Last Updated
6 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

Registry
clinicaltrials.gov
Start Date
September 1, 2016
End Date
July 4, 2019
Last Updated
6 years ago
Study Type
Observational
Sex
Female

Investigators

Sponsor
Shenzhen Center for Disease Control and Prevention
Responsible Party
Principal Investigator
Principal Investigator

Di Li

Doctor

Shenzhen Center for Disease Control and Prevention

Eligibility Criteria

Inclusion Criteria

  • •Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion Criteria

  • •The participants who were not the first visit to the hospital and had been treated before.
  • •The participants who were with endocrine disorders.

Outcomes

Primary Outcomes

the polymorphism in the KISS1/GPR54 pathway genes

Time Frame: 3 months

functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected.

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