Kisspeptin/GPR54 Pathway and Early Puberty
Completed
- Conditions
- Puberty, Precocious
- Registration Number
- NCT04012632
- Lead Sponsor
- Shenzhen Center for Disease Control and Prevention
- Brief Summary
There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 628
Inclusion Criteria
- Clinical diagnosis of central precocious puberty or early and fast puberty.
Exclusion Criteria
- The participants who were not the first visit to the hospital and had been treated before.
- The participants who were with endocrine disorders.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the polymorphism in the KISS1/GPR54 pathway genes 3 months functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected.
- Secondary Outcome Measures
Name Time Method