Detection of circulating tumour cells in cerebrospinal fluid (CSFCTs) to diagnose leptomeningeal metastases (LM) among breast cancer patientsa pilot study
Recruiting
- Conditions
- eptomeningeal metastases among breast cancer patients Nederlands:Leptomeningeale metastasen bij patienten met mammacarcinoom.
- Registration Number
- NL-OMON20288
- Lead Sponsor
- Erasmus Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Breast cancer patients with clinical suspicion of leptomeningeal metastases (LM) who are planned to undergo a lumbar puncture to confirm/exclude the diagnosis LM.
- Signed informed consent.
Exclusion Criteria
- Contra-indication for lumbar puncture (on the discretion of the treating neurologist).
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The detection rate of leptomeningeal metastases as the presence of at least 1 CSFCT in liquor (independent of volume) by the CellSearch method in patients with negative CSF cytology.
- Secondary Outcome Measures
Name Time Method Molecular analysis of CSFCT and CTCs