Effect of Moderate Altitude (>1000 m.a.s.l.) on Sleep Examinations (Polysomnography).
- Conditions
- Healthy
- Interventions
- Diagnostic Test: Polysomnography
- Registration Number
- NCT05826808
- Lead Sponsor
- Tsogyal Latshang
- Brief Summary
The purpose of this study is to investigate the effect of moderate altitude (\>1000 m.a.s.l.) on sleep examinations (polysomnography).
- Detailed Description
Polysomnographies will be done for each participant for 2 consecutive nights at the sleep laboratory in Chur (CH; 600 m.a.s.l.) as well as for 2 consecutive nights at the participants home elevations (CH; \>1000 m.a.s.l.). Between the measurements at those two different altitudes there will be a two-week washout period at \>1000 m.a.s.l.. The sequence of altitude exposure will be randomized.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
- Healthy (no current medical condition or intake of regular medication, except negligible medical issues or accidents not interfering with the current health status or physical performance.)
- Living above 1000 m.a.s.l. since at least 1 year
- No overnight stay at altitudes <1000 m.a.s.l. in the previous 4 weeks
- 18-70 years old
- Body mass index 18,5-30 kg/m2
- informed consent
- Active diseases or health related conditions that require treatment (sleep disorders (mainly sleep apnea), chronic rhinitis, cardiovascular and lung diseases)
- Use of drugs that affect the respiratory center drive (sedatives, sleep inducing drugs, opioids), stimulants or illegal drugs
- Regular consumption of recreational drugs (alcohol and nicotine included)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description B Polysomnography Polysomnographies will be done first for 2 nights at the participants home elevations (\>1000 m.a.s.l.). and after a two-week washout period for 2 nights at sleep laboratory in Chur (600 m.a.s.l.). A Polysomnography Polysomnographies will be done first for 2 nights at the sleep laboratory in Chur (600 m.a.s.l.) and after a two-week washout period for 2 nights at the participants home elevations (\>1000 m.a.s.l.).
- Primary Outcome Measures
Name Time Method T90 (time spent in SpO2 below 90%) 4 nights T90 is the percent of sleeping time which the participant spent in SpO2 below 90%. It provides information about the duration and degree of hypoxia during the whole sleep.
- Secondary Outcome Measures
Name Time Method SWS (slow-wave sleep) 4 nights SWS includes the deep sleep phase. Deep sleep is amongst other important for energy restoration, immune system strengthening and regeneration of cells.
AI (arousal index) 4 nights AI is the number of arousals per hour of sleep, whereby an arousal is an interruption of sleep from 3-15 seconds. They prevent suffocation in the sleep apnea by interrupting breathing pauses but are also coupled with a lot of stress for the human body.
TcCO2 (partial pressure of carbon dioxide) 4 nights TcCO2 correlates with PaCO2 and is therefore a non-invasive alternative. A normal value of PCO2 lies between 35 and 45 mmHg. Lower values can lead to muscle cramps, abnormal heartbeat and much more.
WASO (wakefulness after sleep onset) 4 nights WASO is the time spent awake after sleep onset. High values of WASO are for example found in sleep apnea, insomnia and restless leg syndrome.
ODI (oxygen desaturation index) 4 nights ODI is defined as the number of oxygen decreases ≥3% per hour of sleep.
SpO2 (oxygen saturation) 4 nights SpO2 is the amount of haemoglobin bound to oxygen. Normal values lie above 95%. Values below 90% are considered as low and require treatment.
AHI (apnea-hypopnea index) 4 nights AHI is defined as the number of apneas and hypopneas per hour of sleep, whereby apnea is defined as a cessation of the airflow for ≥10 seconds, while hypopnea is defined as a reduction of the airflow ≥30% with an oxygen desaturation ≥3% or an arousal.
Trial Locations
- Locations (1)
Kantonsspital Graubünden
🇨🇭Chur, Switzerland